Observational studyNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2026
Speech and swallowing rehabilitation in Huntington's disease: clinical outcomes and correlations with disease severity.
Observational study in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionCorticobulbar symptoms, including dysarthria and dysphagia, are frequent manifestations of Huntington's disease, yet evidence on speech and swallowing rehabilitation remains limited. This study explored the potential effects of a home-based corticobulbar rehabilitation program on selected speech and swallowing-related clinical outcomes in Huntington's disease.
methodsThis prospective, non-randomized, observational controlled study included 40 adults with genetically confirmed Huntington's disease. Twenty-five patients entered a 6-month home-based corticobulbar rehabilitation program, while 15 received standard care without structured speech or swallowing rehabilitation. Six patients in the rehabilitation group discontinued the program because of rapid progression of corticobulbar symptoms; therefore, complete-case outcome analyses included 34 patients: 19 rehabilitation completers and 15 controls. Speech and swallowing outcomes were assessed at baseline and month 6 by blinded speech-language pathologists using an exploratory clinical rating scale. Secondary outcomes included body mass index and Unified Huntington's Disease Rating Scale Total Motor Score.
resultsNo intervention-related adverse events were reported among completers. Breathy voice worsened in 6 control patients but in none of the rehabilitation completers (p = 0.004). Speech rate normalization was more frequent in the rehabilitation group than in controls (p = 0.003). Oral residue decreased more frequently in the rehabilitation group, whereas it increased more frequently in controls (p = 0.039). Body mass index was relatively preserved in the rehabilitation group overall (p = 0.025). UHDRS Total Motor Score changes favored rehabilitation but were considered exploratory because motor assessment was not blinded.
conclusionHome-based corticobulbar rehabilitation may be feasible and associated with favorable exploratory changes in selected speech and swallowing parameters in Huntington's disease.
Indexed as
Identifiers
42319517What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.