ArticleMikrochimica acta2026
Enzyme-functionalized electrochemical sensor for unified quantification of multiple bioabsorbable nanoplastic types in human urine.
Article in Mikrochimica acta, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Nanoplastics pose emerging health risk, yet no existing analytical method can quantitatively detect sub‑300 nm nanoplastics in human urine, mainly due to insufficient sensitivity and polymer-dependent limitations. Here, we report a catalase (CAT)‑based electrochemical sensing platform that enables the first quantitative detection of sub‑300 nm nanoplastics in human urine. The sensor leverages a nanoplastic‑induced structural perturbation mechanism, in which hydrophobic‑dominant and electrostatic‑synergistic interactions between nanoplastics and catalase enhance enzymatic activity and generate an amplified electrochemical signal. This mechanism provides unified detection across multiple polymer types and sizes, overcoming the material‑specific limitations of existing analytical approaches. The platform achieves ng·L
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