Evidence map›Paper›PMID 42319458›Full record

ArticleHistochemistry and cell biology2026

Replication stress induced exposure to methotrexate in root meristem cells of Vicia faba.

Żabka Aneta, Natalia Gocek-Szczurtek, Mateusz Wróblewski, Klaudia Cieślak, Justyna Teresa Polit

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In one paragraph

Article in Histochemistry and cell biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Żabka AnetaDepartment of Cytophysiology, Faculty of Biology and Environmental Protection, University of Lodz, 90-236, Lodz, Poland. aneta.zabka@biol.uni.lodz.pl.ORCID http://orcid.org/0000-0001-6401-2068
Natalia Gocek-SzczurtekDepartment of Cytophysiology, Faculty of Biology and Environmental Protection, University of Lodz, 90-236, Lodz, Poland.ORCID http://orcid.org/0000-0001-5484-2340
Mateusz WróblewskiDepartment of Cytophysiology, Faculty of Biology and Environmental Protection, University of Lodz, 90-236, Lodz, Poland.ORCID http://orcid.org/0000-0001-9656-4967
Klaudia CieślakDepartment of Pathomorphology, Synevo, Lodz, Poland.
Justyna Teresa PolitDepartment of Cytophysiology, Faculty of Biology and Environmental Protection, University of Lodz, 90-236, Lodz, Poland.ORCID http://orcid.org/0000-0002-9655-001X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Replication stress (RS) and oxidative stress (OS) are two main types of endogenous stress (ES) which, by inducing various forms of DNA damage lead to genome destabilization and disruption of cell division control mechanisms. Methotrexate (MTX) is a compound that inhibits dihydrofolate reductase (DHFR), thereby blocking DNA replication and exhibiting antiproliferative effects. The aim of the study was to investigate how 72-h exposure to 0.75 mM MTX on meristematic cells of Vicia faba roots affects the morphology of cell nuclei and mitotic chromosomes, population change of cells in interphase, DNA replication dynamics, cell viability, and hydrogen peroxide (H

Indexed as

DNA ReplicationMeristemMethotrexateVicia fabaCell SurvivalHistonesHydrogen PeroxideOxidative StressHistonesHydrogen PeroxideMethotrexateDNA replication stressH3K56AcH4K5AcMethotrexateOxidative stressVicia faba

Identifiers

PMID42319458
PMCPMC13282213

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.