Evidence map›Paper›PMID 42319432›Full record

ArticleHeart and vessels2026

Autonomic modulation in functional tricuspid regurgitation: effects of transcatheter valve repair.

Dominik Nelles, Nesrin Özkan, Johanna Vogelhuber, Marcel Weber, Sebastian Zimmer, Georg Nickenig, Can Öztürk, Christoph Hammerstingl

Abstract read
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In one paragraph

Article in Heart and vessels, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Dominik NellesHeart Center, Department of Medicine II, Herzzentrum Medizinische Klinik Und Poliklinik II, University Hospital Bonn, Bonn, Germany.
Nesrin ÖzkanHeart Center, Department of Medicine II, Herzzentrum Medizinische Klinik Und Poliklinik II, University Hospital Bonn, Bonn, Germany.
Johanna VogelhuberHeart Center, Department of Medicine II, Herzzentrum Medizinische Klinik Und Poliklinik II, University Hospital Bonn, Bonn, Germany.
Marcel WeberHeart Center, Department of Medicine II, Herzzentrum Medizinische Klinik Und Poliklinik II, University Hospital Bonn, Bonn, Germany.
Sebastian ZimmerHeart Center, Department of Medicine II, Herzzentrum Medizinische Klinik Und Poliklinik II, University Hospital Bonn, Bonn, Germany.
Georg NickenigHeart Center, Department of Medicine II, Herzzentrum Medizinische Klinik Und Poliklinik II, University Hospital Bonn, Bonn, Germany.
Can Öztürk *Heart Center, Department of Medicine II, Herzzentrum Medizinische Klinik Und Poliklinik II, University Hospital Bonn, Bonn, Germany. can.oeztuerk@ukbonn.de.ORCID http://orcid.org/0000-0002-5419-2488
Christoph Hammerstingl *Department of Medicine, Kreiskrankenhaus Mechernich, Mechernich, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To assess the impact of functional tricuspid regurgitation (FTR) and transcatheter tricuspid valve repair (TTVR) on sympathetic nerve activity (SNA). Increased SNA is associated with adverse outcomes and reduced survival in patients with valvular heart disease and chronic heart failure (CHF). However, the effect of interventional treatment of FTR on SNA remains unclear. Twenty-eight patients with symptomatic FTR ≥ grade III underwent TTVR (either edge-to-edge repair or direct annuloplasty). Muscle sympathetic nerve activity (MSNA) was assessed via microneurography. While all patients completed the 12-month follow-up, repeated MSNA assessment was feasible in 10. In patients with symptomatic severe FTR, baseline MSNA was markedly elevated (incidence: 192.8 bursts/100 beats; frequency: 167.8 bursts/min). At 12-month follow-up, tricuspid regurgitation severity was significantly reduced (median grade 3 [IQR 3-4] vs. 2 [IQR 1-2]; p < 0.01), accompanied by improved functional status (NYHA class 3 [IQR 3-4] vs. 2 [IQR 1-3], p < 0.01; 53% ≤ NYHA II). NT-proBNP showed a non-significant decline (p = 0.09), while LV function, MR severity, and renal function remained unchanged. MSNA incidence decreased to 72.6 bursts/100 beats (p = 0.01), and frequency to 93.4 bursts/min (p = 0.001). Patients with FTR exhibit markedly increased SNA. TTVR was associated with a significant reduction in MSNA, suggesting a neurophysiological mechanism contributing to clinical improvement beyond hemodynamic relief.

Indexed as

Muscle sympathetic nerve activitySympathetic nerve activityTranscatheter tricuspid valve repairTricuspid regurgitation

Identifiers

PMID42319432

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.