ArticleAmerican journal of reproductive immunology (New York, N.Y. : 1989)2026
Genital Immune Correlates of Seroprevalent and Seroincident Herpes Simplex Type 2 Infection Among Women Who Sell Sex in Nairobi, Kenya.
Article in American journal of reproductive immunology (New York, N.Y. : 1989), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Genital Immune Correlates of Seroprevalent and Seroincident Herpes Simplex Type 2 Infection Among Women Who Sell Sex in Nairobi, Kenya.American journal of reproductive immunology (New York, N.Y. : 1989) · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
17 authors.
Funding
Abstract
problemMost Herpes simplex virus type 2 (HSV-2) infection is asymptomatic but increases the risk of HIV acquisition, possibly due to alterations in genital immunology. We examine associations of HSV-2 prevalence and incidence with epithelial barrier disruption. METHOD OF STUDY: The study was nested within the longitudinal Maisha Fiti cohort of women who sell sex in Nairobi, Kenya. HSV-2 serostatus was assessed by Kalon HSV-2 IgG assay. Socio-behavioural characteristics were assessed by questionnaire and analysed by logistic regression. Immune factors (including soluble E-cadherin (sE-cad)) were assayed in cervicovaginal secretions by multiplex immunoassay, log-transformed and analysed through linear regression.
resultsAmong 731 HIV-negative participants, 414 (57%) were HSV-2 seropositive. These women were older (median age 35 vs 28 years; p < 0.001) and reported increased intravaginal washing (64 vs 56%; p = 0.027) than those who were HSV-2 seronegative. Genital sE-cad levels were similar, and IL-6 levels were lower in seropositive participants (1.15 vs 1.28 pg/mL, p < 0.01). Seroincidence was 10.7/100 person (95% CI: 7.3, 15.2) years among the 317 initially seronegative participants. Incident infection was associated with older age (31 vs 28 years, p = 0.001), increased number of clients (6 vs 4 clients/week, p = 0.005), and bacterial vaginosis (BV) (32 vs 15%, p = 0.009). Although women who acquired HSV-2 had higher sE-cad and lower MIP-3α levels, there was no association after controlling for Nugent score.
conclusionsSubclinical epithelial barrier disruption is unlikely to be underpinning HIV acquisition in asymptomatic HSV-2 infection. There was no evidence of genital immune predictors of HSV-2 acquisition, whereas the vaginal microbiome is important.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.