Trial reportThe journal of extra-corporeal technology2026
A pilot study of the impact of enhanced cardiac index coupled with pulsatile flow on goal direct perfusion during cardiopulmonary bypass.
Trial report in The journal of extra-corporeal technology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
introductionProviding sufficient organ perfusion during cardiopulmonary bypass (CPB) is a common research topic among extracorporeal technology researchers. The application of an elevated cardiac index (CI) to enhance CPB flow, coupled with the adoption of pulsatile flow, constitutes a novel approach designed to improve organ perfusion and oxygen delivery (DO2). this study aims to assess the effects of increased CI and pulsatile flow on organ perfusion during CPB. MATERIAL AND
methodsIn this pilot study, thirty patients scheduled for on-pump coronary artery bypass graft (CABG) surgery with an estimated prolonged CPB time were enrolled. Patients were randomly divided into two study groups. Patients in the control group were managed with a CI of 2.4 L/min/m
resultsParticipants in the study group exhibited lower creatinine levels throughout the assessment period; however, this difference did not reach statistical significance (P > 0.05). Participants in the study group consistently exhibited significantly lower lactate concentrations over the course of the investigation (P < 0.05). Patients in the study groups experienced a reduced duration of both ICU and hospital lengths of stay; however, this difference did not reach statistical significance (P > 0.05).
conclusionThis prospective study concludes that an increased CI in conjunction with PF during CPB can markedly enhance organ perfusion, as evidenced by a statistically significant reduction in lactate production observed throughout the duration of the bypass.
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