Evidence map›Paper›PMID 42319004›Full record

ArticleMolecular pain

Effects of cooling on the excitability of trigeminal Aβ-afferent nociceptors in mice: Involvement of temperature-sensitive K2P channels.

Amit Raj Sharma, Jennifer Ling, Saurav Gupta, Jianguo Gu

Abstract read
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In one paragraph

Article in Molecular pain. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Amit Raj SharmaDepartment of Anesthesiology and Perioperative Medicine, School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
Jennifer LingDepartment of Anesthesiology and Perioperative Medicine, School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
Saurav GuptaDepartment of Anesthesiology and Perioperative Medicine, School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
Jianguo GuDepartment of Anesthesiology and Perioperative Medicine, School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.ORCID 0000-0002-8404-9850

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aβ-afferents are traditionally believed to be low-threshold mechanoreceptors (LTMRs) involved in sensing innocuous mechanical stimuli such as gentle touch; however, emerging evidence indicates that a subset of Aβ-afferents functions as high-threshold mechanoreceptors (HTMRs) involved in mechanical pain and termed Aβ-afferent nociceptors. While cooling is known to usually suppress neuronal excitability, its effects on the excitability of Aβ-afferent nociceptors remain unclear. Here, we used Nav1.8

Indexed as

Cold TemperatureNociceptorsPotassium Channels, Tandem Pore DomainTrigeminal GanglionAction PotentialsAnimalsMaleMembrane PotentialsMiceMice, Inbred C57BLPatch-Clamp TechniquesPotassium Channels, Tandem Pore DomainAβ-afferent nociceptorscoolingexcitabilityintrinsic membrane propertiesK2P channelstrigeminal ganglion

Identifiers

PMID42319004
PMCPMC13329007

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.