ArticleTurkish journal of anaesthesiology and reanimation2026
Efficacy of Intranasal Dexmedetomidine Premedication as an Adjunct on Intubation Process in Paediatric Patients: A Randomized, Double-blind, Placebo-controlled Trial.
Article in Turkish journal of anaesthesiology and reanimation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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6 authors.
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Abstract
Objective: To evaluate the effect of a single intranasal dose of dexmedetomidine (2 μg kg Methods: A randomized, double-blind, placebo-controlled trial was conducted in 40 American Society of Anaesthesiologists I-II children aged 1-6 years who were scheduled for elective surgery. Participants were randomized to receive either dexmedetomidine (n = 20) or 0.9% sodium chloride placebo (n = 20). All patients received intravenous midazolam as a routine premedication. Primary outcomes were mean arterial pressure (MAP) and heart rate (HR), measured at baseline and post-intubation; these were compared to assess intubation efficacy. Secondary outcomes included mask acceptance, sedation quality, intubation time, and total fentanyl consumption. Data were analyzed using the independent-samples t-test or the Mann-Whitney U test ( Results: Dexmedetomidine maintained MAP (1.34±19.59%) versus a significant rise with placebo (21.95±26.36%; P=0.008) and limited HR increase (1.6% vs. 22.2%; Conclusion: A single intranasal dose of dexmedetomidine provides superior intubation efficacy, improves mask acceptance and sedation quality, and yields a significant opioid-sparing effect.
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