Evidence map›Paper›PMID 42318673›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

Antigen Spreading via Localized Administration Enhances Adoptive TCR-T Cell Therapy in Pancreatic Cancer.

Junming Huang, Qin Wang, Zhuo Yao, Qing Wang, Yongtao Ji, Minqi Yang, Meng Wang, Shiyi Shao, Xinyu Zhao, Fu Zhang and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Junming HuangDepartment of Hepatobiliary and Pancreatic Surgery, School of Medicine, the First Affiliated Hospital, Zhejiang University, Hangzhou, Zhejiang, China.
Qin WangDepartment of Hepatobiliary and Pancreatic Surgery, School of Medicine, the First Affiliated Hospital, Zhejiang University, Hangzhou, Zhejiang, China.
Zhuo YaoDepartment of Hepatobiliary and Pancreatic Surgery, School of Medicine, the First Affiliated Hospital, Zhejiang University, Hangzhou, Zhejiang, China.ORCID https://orcid.org/0009-0004-5552-2567
Qing WangDepartment of Hepatobiliary and Pancreatic Surgery, School of Medicine, the First Affiliated Hospital, Zhejiang University, Hangzhou, Zhejiang, China.
Yongtao JiDepartment of Hepatobiliary and Pancreatic Surgery, School of Medicine, the First Affiliated Hospital, Zhejiang University, Hangzhou, Zhejiang, China.
Minqi YangDepartment of Hepatobiliary and Pancreatic Surgery, School of Medicine, the First Affiliated Hospital, Zhejiang University, Hangzhou, Zhejiang, China.
Meng WangZhejiang Provincial Key Laboratory of Pancreatic Disease, School of Medicine, the First Affiliated Hospital, Zhejiang University, Hangzhou, Zhejiang, China.
Shiyi ShaoDepartment of Hepatobiliary and Pancreatic Surgery, School of Medicine, the First Affiliated Hospital, Zhejiang University, Hangzhou, Zhejiang, China.
Xinyu ZhaoDepartment of Hepatobiliary and Pancreatic Surgery, School of Medicine, the First Affiliated Hospital, Zhejiang University, Hangzhou, Zhejiang, China.
Fu ZhangDepartment of Hepatobiliary and Pancreatic Surgery, School of Medicine, the First Affiliated Hospital, Zhejiang University, Hangzhou, Zhejiang, China.
Tingbo LiangDepartment of Hepatobiliary and Pancreatic Surgery, School of Medicine, the First Affiliated Hospital, Zhejiang University, Hangzhou, Zhejiang, China.ORCID https://orcid.org/0000-0003-1233-9725
Qida HuDepartment of Hepatobiliary and Pancreatic Surgery, School of Medicine, the First Affiliated Hospital, Zhejiang University, Hangzhou, Zhejiang, China.ORCID https://orcid.org/0000-0002-9092-7808

Funding

National Natural Science Foundation of China 82100645National Natural Science Foundation of China 82188102National Natural Science Foundation of China 82273488National Natural Science Foundation of China 82573472National Natural Science Foundation of China U20A20378
6 · The paper itself

Abstract

Cancer vaccines have demonstrated initial effectiveness in the treatment of human cancers, still the low mutational burden, which leads to a deficiency of well-characterized antigens expressed within tumors capable of mediating tumor rejection, poses a significant challenge in pancreatic cancer. Here, we introduce an ionic liquid ILvax for localized tumor administration, which elicits a systemic and antigen-specific anti-tumor immune response, thereby generating a vaccine-like effect. Type 1 conventional dendritic cells (cDC1) is the determinant for systemic immune response. ILvax ablation facilitates migration of tumor antigen-carrying cDC1 to peripheral lymphoid organs, thus initiating the cDC1-mediated antigen presentation cascade that results in an amplified antigen-specific T cells response. Meanwhile, cDC1-mediated antigen spreading induced by ILvax enabled the expansion of adoptive TCR-T while shifting TCR-T metabolism toward oxidative phosphorylation (OXPHOS). Localized tumor administration with ILvax simultaneously enhances the functionality of both endogenous CD8

Indexed as

Antigens, NeoplasmCancer VaccinesImmunotherapy, AdoptivePancreatic NeoplasmsReceptors, Antigen, T-CellAnimalsCD8-Positive T-LymphocytesDendritic CellsHumansMiceMice, Inbred C57BLAntigens, NeoplasmCancer VaccinesReceptors, Antigen, T-Cellantigenantigen presentationcancercancer researchcd8cell therapyimmune systemmedicinepancreatic cancer

Identifiers

PMID42318673
PMCPMC13336903

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.