ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026
Mood Disorder Begins in the Mouth: Periodontitis Mediates Anxiety-Like Behaviors.
Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Abstract
The previous study elucidated that the C-reactive protein (CRP)/bone morphogenetic protein 4 (BMP4) signaling pathway mediates periodontitis-associated anxiety-like behaviors in rats. This molecular crosstalk along the periodontal-hippocampal axis provides novel insights into the etiology and mechanisms of emotional disorders. However, several key issues remain to be further discussed regarding the establishment of the core finding linking peripheral inflammation to emotional disorders and potential translational significance. Here, this commentary analyzes the mechanisms underlying CRP entry into the brain, the choice of behavioral paradigms for emotional assessment, the possible dynamic evolution of the pathogenesis, and the translational potential of CRP, with the aim of fostering constructive academic discussion.
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