Evidence map›Paper›PMID 42318630›Full record

ArticleJournal of medical primatology2026

Clinical Management of Helicobacter Infection in Captive Baboons (Papio anubis and Papio hamadryas), and Isolation and Molecular Characterization of Three Novel Helicobacter Species.

Isabel A Jimenez, Courtney Lunger, Marcus J Crim, Shannon L Primm, Anthony Mannion, Nathan P Crilly, Lydia M Hopper, Lindsey G Thurman, Linnette L Vasquez, Cory Brayton and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of medical primatology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Isabel A JimenezDepartment of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.ORCID https://orcid.org/0000-0002-5384-7809
Courtney LungerDivision of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.ORCID https://orcid.org/0009-0009-4070-8824
Marcus J CrimIDEXX BioAnalytics, Columbia, Missouri, USA.ORCID https://orcid.org/0000-0001-6705-831X
Shannon L PrimmIDEXX BioAnalytics, Columbia, Missouri, USA.ORCID https://orcid.org/0009-0002-5087-8826
Anthony MannionDivision of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.ORCID https://orcid.org/0000-0002-6112-0546
Nathan P CrillyDepartment of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.ORCID https://orcid.org/0000-0003-1626-2809
Lydia M HopperDepartment of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.ORCID https://orcid.org/0000-0001-5953-3264
Lindsey G ThurmanDepartment of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.ORCID https://orcid.org/0000-0001-9444-2130
Linnette L VasquezDepartment of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Cory BraytonDepartment of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.ORCID https://orcid.org/0000-0002-6666-6548
Yan FengDivision of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.
James G FoxDivision of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.ORCID https://orcid.org/0000-0001-9307-6116
Zeli ShenDivision of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.
Jessica M IzziDepartment of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

Funding

The Role of Stem Cells and the Microenvironment in Gastrointestinal CancersR35CA210088 · NCI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Timothy Cragin Wang · 2017 to 2026
$10.2M
Training Veterinarians for Careers in Biomedical ResearchT32OD011089 · OD · JOHNS HOPKINS UNIVERSITY · PI JOSEPH L MANKOWSKI · 2012 to 2026
$6.7M
IDEXX BioAnalyticsJohns Hopkins UniversityMassachusetts Institute of TechnologyNIH HHS 1R01 CA281732-01NIH HHS R35 CA210088NIH HHS T32 OD011089
6 · The paper itself

Abstract

backgroundHelicobacter spp. are gastric or enterohepatic bacteria that can be commensal, opportunistic, or pathogenic. Few studies have evaluated Helicobacter spp. in baboons.

methodsTwenty-seven captive baboons were surveyed for Helicobacter spp. by fecal PCR, and a subset evaluated by culture. Nine baboons were treated with oral "triple therapy" with clarithromycin (10 mg/kg), amoxicillin (10 mg/kg), and omeprazole (20 mg) once daily for 10 days.

resultsAll baboons were positive for Helicobacter spp., including H. macacae (78%), H. suis (19%), and H. pylori (15%). Three novel Helicobacter species were identified by whole genomic sequencing, for which we propose the names Helicobacter papionis, H. simiae, and H. papionifaecis. Treatment was safe and effective for H. pylori, H. suis, and H. macacae, but did not eliminate the novel Helicobacter spp.

conclusionsSpecies-specific assays should guide treatment of Helicobacter spp. infections in baboons. Further epidemiologic studies are needed to inform clinical management.

Indexed as

Anti-Bacterial AgentsHelicobacterHelicobacter InfectionsMonkey DiseasesPapio anubisPapio hamadryasAmoxicillinAnimalsClarithromycinDrug Therapy, CombinationFecesFemaleMaleOmeprazolePolymerase Chain ReactionAmoxicillinAnti-Bacterial AgentsClarithromycinOmeprazolecaptive managemententerohepatic Helicobacterfecal PCRsurveillance

Identifiers

PMID42318630
PMCPMC13280779

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.