Evidence map›Paper›PMID 42318604›Full record

ArticleEpigenomics2026

Promoter methylation-associated brain-enriched long noncoding RNAs in glioblastoma: a multi-cohort public epigenomic re-analysis.

Ye Tan, Fengyu Cheng, Pu Li, Jingxuan Xiang, Yuhong Tang, Aidong Chen, Peiying Han

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Article in Epigenomics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Ye TanDepartment of Clinical Medicine, Kangda College of Nanjing Medical University, Lianyungang, China.
Fengyu ChengThe First People's Hospital of Lianyungang, The Lianyungang Clinical College of Nanjing Medical University, The Affiliated Lianyungang Hospital of Xuzhou Medical University, The First Affiliated Hospital of Kangda College of Nanjing Medical University, Lianyungang, China.
Pu LiDepartment of Orthopedics, Siyang First People's Hospital, Suqian, China.
Jingxuan XiangThe Key Laboratory of Targeted Intervention of Clinical Disease, Nanjing Medical University, Nanjing, China.
Yuhong TangDepartment of Clinical Medicine, Kangda College of Nanjing Medical University, Lianyungang, China.
Aidong ChenThe Key Laboratory of Targeted Intervention of Clinical Disease, Nanjing Medical University, Nanjing, China.
Peiying HanNursing Department, Nanjing Drum Tower Hospital, Nanjing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundGlioblastoma (GBM) is epigenetically heterogeneous, and previous long noncoding RNA (lncRNA) methylation studies have often begun from tumor-wide screens. We asked whether brain-enriched lncRNAs show promoter methylation-associated suppression in GBM. RESEARCH DESIGN AND

methodsBrain-enriched lncRNAs were defined using GENCODE v49 and GTEx/UCSC Xena. Primary discovery used TCGA-GBM primary tumors with matched expression and promoter methylation; 52 patients had both data types. Spearman correlations identified methylation-associated candidates (

resultsOf 13,213 lncRNAs, 437 were brain-enriched and 76 entered matched TCGA analysis; seven met core criteria. PTPRD-AS1 and NFIB-AS1 showed the strongest inverse coupling (

conclusionsThis public-data re-analysis prioritizes brain-enriched lncRNAs associated with promoter hypermethylation and lower expression in GBM, but does not establish direct methylation-mediated silencing.

Indexed as

Brain NeoplasmsDNA MethylationGlioblastomaPromoter Regions, GeneticRNA, Long NoncodingBrainEpigenesis, GeneticEpigenomicsGene Expression Regulation, NeoplasticHumansRNA, Long Noncodingbrain-enriched long noncoding RNAGlioblastomamethylation-expression associationpromoter methylationpublic-data re-analysissingle-cell validation

Identifiers

PMID42318604
PMCPMC13390522

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.