Evidence map›Paper›PMID 42318589›Full record

ArticleJournal of research in medical sciences : the official journal of Isfahan University of Medical Sciences2026

Latent autoimmune diabetes mellitus and its characteristics amongst adults diagnosed with type 2 diabetes at a single diabetes center in Medina, Saudi Arabia.

Eman Alfadhli, Walaa Mohammedsaeed, Amal Surrati, Mashael Alharbi, Mansour Alharbi, Zain Alghamdi

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Article in Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Eman AlfadhliMedicine Department, College of Medicine, Taibah University, Madina, Saudi Arabia.
Walaa MohammedsaeedClinical Laboratory Sciences Department, Faculty of Applied Medical Science, Taibah University, Medina, Saudi Arabia.
Amal SurratiFamily, Community Medicine and Medical Education Department, College of Medicine, Taibah University, Medina, Saudi Arabia.
Mashael AlharbiDiabetes Center Department, AL-Iman General Hospital, Riyadh First Health Cluster, Riyadh, Saudi Arabia.
Mansour AlharbiDiabetes Center Department, King Fahd Hospital, Medina, Saudi Arabia.
Zain AlghamdiEndocrinology Department, King Salman Medical City, Medina, Saudi Arabia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: To estimate the frequency and characteristics of Latent Autoimmune Diabetes in Adults (LADA) in patients diagnosed with type 2 diabetes mellitus (T2DM) at a single diabetes center in Medina, Saudi Arabia. Materials and Methods: This was a cross-sectional study involving patients with T2DM aged 30-70 years with a disease duration of ≤5 years, and who had not received insulin for at least 6 months post-T2DM diagnosis. Demographics, anthropometrics, autoantibodies to Glutamic Acid Decarboxylase Autoantibodies (GADA) and islet cell antibodies (ICA), serum C-peptide, glycated hemoglobin (HbA1C), and lipid data were collected. LADA was diagnosed according to GADA and/or ICA positivity. Participants were classified into two groups: LADA and non-LADA. The clinical and biochemical characteristics of both groups were compared. Results: A total of 157 participants (mean age 50 years, 52.9% male) were enrolled, with 30 (19.1%) testing positive for GADA and/or ICA. Among them, 16 (10.2%) were positive for GADA alone, 9 (5.7%) tested positive for ICA alone, and 5 (3.2%) tested positive for both GADA and ICA. GADA was significantly more prevalent in younger individuals (30-49 years, Conclusion: The study reveals a high rate of LADA within this cohort of Saudi patients diagnosed with T2DM. LADA patients display some clinical and biochemical characteristics that set them apart from conventional T2DM cases. Screening for β-cell autoantibodies in individuals with these features could aid in earlier diagnosis of LADA and allow for more tailored treatment approaches.

Indexed as

AutoimmuneC-peptidediabetes mellitusglutamate decarboxylase/immunologyislet cell antibodiestype 2 diabetes mellitus

Identifiers

PMID42318589
PMCPMC13274942

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