ArticleEpilepsy & behavior reports2026
Qualitative EEG morphology predicts early Antiseizure medication response in newly diagnosed epilepsy: A prospective cohort study.
Article in Epilepsy & behavior reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Epilepsy is a complex neurological disorder with diverse electroclinical characteristics. While diagnosis is guided by the ILAE 2025 classification, the prognostic value of specific interictal epileptiform discharge (IED) morphologies for initial antiseizure medication (ASM) selection remains incompletely characterized. Objective: To determine whether qualitative EEG characteristics at diagnosis predict early ASM responsiveness across six major epilepsy syndromes. Methods: In this prospective cohort study, 150 newly diagnosed, drug-naïve patients (25 per syndrome) including Focal Epilepsy, FBTCS, BECTS, CAE, GGE, and JME underwent standardized baseline EEG with activation procedures. ASMs were prescribed according to routine clinical practice. Follow-up clinical evaluation and EEG were performed at 3 months. The primary outcome was EEG normalization; secondary outcomes included ≥50% seizure reduction and seizure freedom. Results: EEG normalization rates varied significantly across syndromes, ranging from 76% in CAE to 20% in FBTCS. Qualitative IED morphology was associated with normalization ( Conclusion: In well-defined electroclinical syndromes, qualitative IED morphology appears to provide additional prognostic information regarding early ASM response. These findings suggest that EEG morphology may complement syndrome-based assessment and that variability in spike and sharp-wave morphology may reflect underlying electrophysiological heterogeneity extending beyond fixed syndrome labels, supporting further investigation using standardized morphology analysis in larger, controlled studies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.