Evidence map›Paper›PMID 42318536›Full record

ArticleKidney international reports2026

A Clinicopathologic Study of Neural Epidermal Growth Factor-Like 1-Associated Membranous Nephropathy in a Chinese Cohort.

Jing Xu, Xiaofan Hu, Ye Zhu, Xialian Yu, Dujuan Hua, Weiming Wang, Muyin Zhang, Manman Shi, Yuhua Ma, Zhiyuan Liu and 3 more

Abstract read
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In one paragraph

Article in Kidney international reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Jing XuDepartment of Nephrology, Shanghai Ruijin Hospital, Institute of Nephrology, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Xiaofan HuDepartment of Nephrology, Shanghai Ruijin Hospital, Institute of Nephrology, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Ye ZhuDepartment of Nephrology, Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu Province, China.
Xialian YuDepartment of Nephrology, Shanghai Ruijin Hospital, Institute of Nephrology, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Dujuan HuaDepartment of Nephrology, Shanghai Ruijin Hospital, Institute of Nephrology, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Weiming WangDepartment of Nephrology, Shanghai Ruijin Hospital, Institute of Nephrology, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Muyin ZhangDepartment of Nephrology, Shanghai Ruijin Hospital, Institute of Nephrology, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Manman ShiDepartment of Nephrology, Kunshan Hospital of Chinese Medicine, Suzhou, Jiangsu Province, China.
Yuhua MaDepartment of Nephrology, Kunshan Hospital of Chinese Medicine, Suzhou, Jiangsu Province, China.
Zhiyuan LiuDepartment of Nephrology, Sihong County First People's Hospital, Suqian, Jiangsu Province, China.
Xiujuan ZangDepartment of Nephrology, Songjiang Hospital affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Jingyuan XieDepartment of Nephrology, Shanghai Ruijin Hospital, Institute of Nephrology, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Xiaoxia PanDepartment of Nephrology, Shanghai Ruijin Hospital, Institute of Nephrology, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Neural epidermal growth factor-like 1 (NELL-1)-associated membranous nephropathy (MN), first described in 2020, represents a common subtype among >20 target antigens; however, its clinicopathologic features and long-term prognosis are poorly characterized. Methods: Consecutive biopsy-proven MN cases (2006-2025) were retrospectively analyzed at Ruijin Hospital, Shanghai. NELL-1 immunostaining was performed in M-type phospholipase A Results: Of 556 PLA2R- and THSD7A-negative MN cases, 12.2% ( Conclusion: NELL-1-associated MN occurs at a relatively younger age in women, whereas malignancy predominantly occurred in elderly men in Han Chinese population. Diffuse deposition was associated with higher proteinuria. Overall prognosis was favorable, except in malignancy-associated cases, suggesting malignancy screening at diagnosis, particularly in elderly men.

Indexed as

agelong-term prognosismalignancymembranous nephropathy (MN)neural epidermal growth factor-like 1 protein (NELL-1)pathology pattern

Identifiers

PMID42318536
PMCPMC13273827

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