Evidence map›Paper›PMID 42318454›Full record

ArticleThe annals of applied statistics2025

TREATMENT EFFECT HETEROGENEITY AND IMPORTANCE MEASURES FOR MULTIVARIATE CONTINUOUS TREATMENTS.

Heejun Shin, Antonio Linero, Michelle Audirac, Kezia Irene, Danielle Braun, Joseph Antonelli

Abstract read
In one paragraph

Article in The annals of applied statistics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Heejun ShinDepartment of Biostatistics, Harvard T.H. Chan School of Public Health.ORCID 0000-0003-2733-6957
Antonio LineroDepartment of Statistics and Data Science, University of Texas at Austin.
Michelle AudiracDepartment of Biostatistics, Harvard T.H. Chan School of Public Health.
Kezia IreneDepartment of Biostatistics, Harvard T.H. Chan School of Public Health.
Danielle BraunDepartment of Biostatistics, Harvard T.H. Chan School of Public Health.
Joseph AntonelliDepartment of Statistics, University of Florida.

Funding

National Cohort Studies of Alzheimer's Disease, Related Dementias and Air PollutionR01AG066793 · NIA · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI ZANOBETTI, ANTONELLA · 2020 to 2025
$4.2M
Integrating Air Pollution Prediction Models: Uncertainty Quantification and Propagation in Health StudiesR01ES030616 · NIEHS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI DOMINICI, FRANCESCA, KIOUMOURTZOGLOU, MARIANTHI-ANNA · 2020 to 2024
$3.1M
(R01 Transfer) Characterizing the link between multiple environmental exposures and Parkinsons disease exacerbationR01ES034373 · NIEHS · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · PI Danielle Braun, Antonella Zanobetti · 2022 to 2026
$2.9M
Susceptibility and adverse health outcomes related to climate-sensitive events among older Medicare beneficiaries with Alzheimer and DementiaRF1AG080948 · NIA · YALE UNIVERSITY · PI BELL, MICHELLE L, BENMARHNIA, TARIK · 2023 to 2023
$2.6M
The confluence of extreme heat cold on the health and longevity of an Aging Population with Alzheimers and related DementiaRF1AG074372 · NIA · HARVARD MEDICAL SCHOOL · PI DOMINICI, FRANCESCA, ESTIRI, HOSSEIN · 2022 to 2023
$2.6M
Statistical methods to characterize causal mechanisms by which air pollution affects the recurrence of cardiovascular eventsR01ES034021 · NIEHS · UNIVERSITY OF ROCHESTER · PI Francesca Dominici, Ashkan Ertefaie · 2023 to 2026
$2.5M
Short and long-term consequences of wildfires for Alzheimer's disease and related dementias.RF1AG071024 · NIA · UNIVERSITY OF WASHINGTON · PI CASEY, JOAN A · 2021 to 2022
$2.4M
NIA NIH HHS R01 AG066793NIA NIH HHS RF1 AG071024NIA NIH HHS RF1 AG074372NIA NIH HHS RF1 AG080948NIEHS NIH HHS R01 ES030616NIEHS NIH HHS R01 ES034021NIEHS NIH HHS R01 ES034373
6 · The paper itself

Abstract

Estimating the joint effect of a multivariate, continuous exposure is crucial, particularly in environmental health where interest lies in simultaneously evaluating the impact of multiple environmental pollutants on health. We develop novel methodology that addresses two key issues for estimation of treatment effects of multivariate, continuous exposures. We use nonparametric Bayesian methodology that is flexible to ensure our approach can capture a wide range of data generating processes. Additionally, we allow the effect of the exposures to be heterogeneous with respect to covariates. Treatment effect heterogeneity has not been well explored in the causal inference literature for multivariate, continuous exposures, and, therefore, we introduce novel estimands that summarize the nature and extent of the heterogeneity and propose estimation procedures for new estimands related to treatment effect heterogeneity. We provide theoretical support for the proposed models in the form of posterior contraction rates and show that it works well in simulated examples both with and without heterogeneity. Our approach is motivated by a study of the health effects of simultaneous exposure to the components of PM

Indexed as

Bayesian nonparametricsCausal inferenceenvironmental mixturestreatment effect heterogeneityvariable importance measures

Identifiers

PMID42318454
PMCPMC13274635

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.