ArticleRSC chemical biology2026
Reversible formation of
Article in RSC chemical biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
8 authors.
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Abstract
A spontaneous cyclization of 1,3-bisphosphoglycerate produces a highly reactive cyclic 3-phosphoglyceric anhydride (cPGA), which damages cellular nucleophiles through indiscriminate acylation. Although evidence suggests that most of the cPGA is inactivated by DJ-1, a highly efficient cPGA hydrolase, alternative routes of cPGA detoxification have not been explored. Here, we use a kinetic approach to show that a thiol group of glutathione (GSH) reacts with cPGA to produce the corresponding thioester
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.