ArticleLaryngoscope investigative otolaryngology2026
Viral Detection and Clinical Disease Features in Pediatric Chronic Rhinosinusitis.
Article in Laryngoscope investigative otolaryngology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objectives: Chronic rhinosinusitis (CRS) results from complex host-environment interactions with microbiome dysbiosis and viral infections postulated to drive inflammation and anatomic remodeling. This study investigates the impact of viral presence on pediatric sinonasal disease and clinical outcomes. Methods: A prospective, case-control study with retrospective data collection was conducted at a single-institution tertiary children's hospital. Pediatric patients undergoing sinus surgery for CRS (cystic fibrosis [CF] and non-CF CRS groups) and a control group undergoing structural septoplasty were enrolled from 2018-2022. Sinus swabs were collected intraoperatively and during up to 3 years of follow-up. A 14-virus panel was run. 16S and custom amplicon sequencing and quantitative PCR assessed microbial profiles. Clinical and endoscopic data were recorded. Results: Sinonasal swabs were collected from 15 CF-CRS, 21 non-CF CRS, and 32 control patients during initial sinus surgery. At least one virus was detected in 30.9% of samples ( Conclusion: Viral infections can exacerbate pediatric CRS by increasing nasal drainage and endoscopic discharge while promoting chronic inflammation and persistent disease. Level of Evidence: 4.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.