Parallelized contactless microfluidic dispenser with superhydrophobic nozzles for scalable combinatorial screening.

Niphattha Wongwiset, Morgan L Stephens, Blanca I Quiñones-Díaz, Aryan Mehboudi, Lydia M Contreras, S V Sreenivasan

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Article in Biomicrofluidics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0 citing papers in PubMed.

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5 · Who and what money

Authors and funding

6 authors.

Niphattha WongwisetWalker Department of Mechanical Engineering, the University of Texas at Austin, 10100 Burnet Road, 1.206 MER Bldg. 160, Austin, Texas, USA.

Morgan L StephensMcKetta Department of Chemical Engineering, the University of Texas at Austin, 200 E. Dean Keeton St., Stop C0400, Austin, Texas, USA.

Blanca I Quiñones-DíazMcKetta Department of Chemical Engineering, the University of Texas at Austin, 200 E. Dean Keeton St., Stop C0400, Austin, Texas, USA.

Aryan MehboudiNASCENT, the University of Texas at Austin, 10100 Burnet Road, 1.206 MER Bldg. 160, Austin, Texas, USA.

Lydia M ContrerasMcKetta Department of Chemical Engineering, the University of Texas at Austin, 200 E. Dean Keeton St., Stop C0400, Austin, Texas, USA.

S V SreenivasanWalker Department of Mechanical Engineering, the University of Texas at Austin, 10100 Burnet Road, 1.206 MER Bldg. 160, Austin, Texas, USA.

Funding

Novel mechanisms of posttranscriptional regulation by CsrAR01GM135495 · NIGMS · UNIVERSITY OF TEXAS AT AUSTIN · PI CONTRERAS, LYDIA MARIA · 2020 to 2024

$1.8M

NIGMS NIH HHS R01 GM135495

6 · The paper itself

Abstract

While high-throughput combinatorial sample generation plays a critical role in drug discovery and cell-based assays, standard methods have encountered challenges of time or cost-effectiveness when using manual preparation or serial-dispensing liquid handlers. To address these challenges, we introduce a novel parallel combinatorial microfluidic (PCM) system that applies the design of hydraulic-resistance networks to simultaneously generate a prespecified combinatorial map. Unlike conventional serial dispensing, PCM devices integrated superhydrophobic outlets for parallel contactless dispensing, thereby minimizing contamination, reducing processing time, and ensuring an identical reaction time across all samples. Regardless of the number of target samples, the PCM system demonstrated rapid operation by completing all processes within 5 minutes. Devices fabricated for multiple combinatorial maps validated the PCM design principle and high-throughput scalability by reliably producing the predefined maps with droplet sizes of 3.5

Identifiers

PMID42318231

DOI10.1063/5.0321277

PMCPMC13275110

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.