Evidence map›Paper›PMID 42318210›Full record

ArticleFrontiers in endocrinology2026

Resolved hyperthyroidism before IVF is not associated with improved cumulative live birth rates: a retrospective cohort study.

Huizi Jin, Jiejun Luo, Menglu Wu, Yuxuan Fang, Zijin Xu, Lin Zhu, Mingzhu Cao, Zhu Liang, Jing Wang, Yanshan Lin and 4 more

Abstract read
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In one paragraph

Article in Frontiers in endocrinology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

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No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Huizi Jin *Department of Obstetrics and Gynecology, Center for Reproductive Medicine; Guangdong Provincial Key Laboratory of Major Obstetrics Disease; Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology; Guangdong-Hong Kong-Macao Greater Bay Area Higher Education Joint Laboratory of Maternal-Fetal Medicine; The Third Affiliated Hospital, Guangzhou Medical University, Guangzhou, China.
Jiejun Luo *Department of Obstetrics and Gynecology, Center for Reproductive Medicine; Guangdong Provincial Key Laboratory of Major Obstetrics Disease; Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology; Guangdong-Hong Kong-Macao Greater Bay Area Higher Education Joint Laboratory of Maternal-Fetal Medicine; The Third Affiliated Hospital, Guangzhou Medical University, Guangzhou, China.
Menglu WuDepartment of Obstetrics and Gynecology, Center for Reproductive Medicine; Guangdong Provincial Key Laboratory of Major Obstetrics Disease; Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology; Guangdong-Hong Kong-Macao Greater Bay Area Higher Education Joint Laboratory of Maternal-Fetal Medicine; The Third Affiliated Hospital, Guangzhou Medical University, Guangzhou, China.
Yuxuan FangDepartment of Biomedical Engineering, City University of Hong Kong, Hong Kong, Hong Kong SAR, China.
Zijin XuDepartment of Obstetrics and Gynecology, Center for Reproductive Medicine; Guangdong Provincial Key Laboratory of Major Obstetrics Disease; Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology; Guangdong-Hong Kong-Macao Greater Bay Area Higher Education Joint Laboratory of Maternal-Fetal Medicine; The Third Affiliated Hospital, Guangzhou Medical University, Guangzhou, China.
Lin ZhuDepartment of Obstetrics and Gynecology, Center for Reproductive Medicine; Guangdong Provincial Key Laboratory of Major Obstetrics Disease; Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology; Guangdong-Hong Kong-Macao Greater Bay Area Higher Education Joint Laboratory of Maternal-Fetal Medicine; The Third Affiliated Hospital, Guangzhou Medical University, Guangzhou, China.
Mingzhu CaoDepartment of Obstetrics and Gynecology, Center for Reproductive Medicine; Guangdong Provincial Key Laboratory of Major Obstetrics Disease; Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology; Guangdong-Hong Kong-Macao Greater Bay Area Higher Education Joint Laboratory of Maternal-Fetal Medicine; The Third Affiliated Hospital, Guangzhou Medical University, Guangzhou, China.
Zhu LiangDepartment of Obstetrics and Gynecology, Center for Reproductive Medicine; Guangdong Provincial Key Laboratory of Major Obstetrics Disease; Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology; Guangdong-Hong Kong-Macao Greater Bay Area Higher Education Joint Laboratory of Maternal-Fetal Medicine; The Third Affiliated Hospital, Guangzhou Medical University, Guangzhou, China.
Jing WangDepartment of Obstetrics and Gynecology, Center for Reproductive Medicine; Guangdong Provincial Key Laboratory of Major Obstetrics Disease; Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology; Guangdong-Hong Kong-Macao Greater Bay Area Higher Education Joint Laboratory of Maternal-Fetal Medicine; The Third Affiliated Hospital, Guangzhou Medical University, Guangzhou, China.
Yanshan LinDepartment of Obstetrics and Gynecology, Center for Reproductive Medicine; Guangdong Provincial Key Laboratory of Major Obstetrics Disease; Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology; Guangdong-Hong Kong-Macao Greater Bay Area Higher Education Joint Laboratory of Maternal-Fetal Medicine; The Third Affiliated Hospital, Guangzhou Medical University, Guangzhou, China.
Yixuan WuDepartment of Obstetrics and Gynecology, Center for Reproductive Medicine; Guangdong Provincial Key Laboratory of Major Obstetrics Disease; Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology; Guangdong-Hong Kong-Macao Greater Bay Area Higher Education Joint Laboratory of Maternal-Fetal Medicine; The Third Affiliated Hospital, Guangzhou Medical University, Guangzhou, China.
Wenju PengDivision of Gynecologic Oncology in the Department of Obstetrics and Gynecology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.
Haiying LiuDepartment of Obstetrics and Gynecology, Center for Reproductive Medicine; Guangdong Provincial Key Laboratory of Major Obstetrics Disease; Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology; Guangdong-Hong Kong-Macao Greater Bay Area Higher Education Joint Laboratory of Maternal-Fetal Medicine; The Third Affiliated Hospital, Guangzhou Medical University, Guangzhou, China.
Jian-Qiao LiuDepartment of Obstetrics and Gynecology, Center for Reproductive Medicine; Guangdong Provincial Key Laboratory of Major Obstetrics Disease; Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology; Guangdong-Hong Kong-Macao Greater Bay Area Higher Education Joint Laboratory of Maternal-Fetal Medicine; The Third Affiliated Hospital, Guangzhou Medical University, Guangzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Hyperthyroidism adversely impacts female reproduction, yet its association with Methods: This retrospective study included patients undergoing their first oocyte retrieval cycle from January 2014 to September 2022, the follow-up lasted for two years. Thyroid function (TSH, FT3, FT4) was classified using the most recent test performed within 3 months before oocyte retrieval. Patients were categorized into three groups: AH, RH, and NC group based on the thyroid hormone level and disease history. The primary outcome was cumulative live birth rate (CLBR) per aspiration cycle. Multivariable logistic regression and inverse probability weighting (IPW) were used to evaluate the association, with adjustment for baseline characteristics and treatment protocols. Subgroup analysis examined the association between hyperthyroidism duration and CLBRs in patients in the AH/RH groups. Results: 17,621 patients were involved, with 257 in the AH group, 297 in the RH group, and 17,067 in the NC group. The fresh cycle LBR was significantly lower in group AH compared to NC (31.9% vs. 43.7%, P = 0.034). CLBRs were 42.3% in group AH, 44.1% in RH, and 54.9% in NC. Adjusted models revealed lower LBR and CLBR in group AH versus NC, and no significant differences between group AH and RH. In the subgroup of patients with hyperthyroidism, longer duration of hyperthyroidism was negatively associated with cumulative live birth (aOR=0.9990 (0.9985-0.9995), P< 0.001). Conclusions: Preconception hyperthyroidism was associated with poorer IVF outcomes, and longer disease duration was associated with a lower CLBR.

Indexed as

Birth RateFertilization in VitroHyperthyroidismInfertility, FemaleLive BirthAdultFemaleFollow-Up StudiesHumansOocyte RetrievalPregnancyPregnancy RateRetrospective Studiescumulative live birth ratefertilityhyperthyroidismin vitro fertilizationlive birth rateresolved hyperthyroidism

Identifiers

PMID42318210
PMCPMC13273757

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.