Therapeutic impact of Mongolian Andai therapy on gut microbiota and metabolomic profiles in depression.

Qila Sa, Miao Mei, Yuanyuan Ma, Yunfei Niu, Murilige Chao, Yagetu Hu, Yumei Qi

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Article in Frontiers in neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Qila Sa *Ethnic Medicine Innovation Center, Inner Mongolia Medical University, Hohhot, Inner Mongolia, China.

Miao Mei *Five-Therapy Rehabilitation Department, Inner Mongolia International Mongolian Medicine Hospital, Hohhot, Inner Mongolia, China.

Yuanyuan MaMongolian Medicine Department, Affiliated Hospital of Inner Mongolia Medical University, Hohhot, Inner Mongolia, China.

Yunfei NiuAffective Disorder Treatment Department, Inner Mongolia Mental Health Center, Hohhot, Inner Mongolia, China.

Murilige ChaoEthnic Medicine Innovation Center, Inner Mongolia Medical University, Hohhot, Inner Mongolia, China.

Yagetu HuHematology Department, Inner Mongolia International Mongolian Medicine Hospital, Hohhot, Inner Mongolia, China.

Yumei QiAffective Disorder Treatment Department, Inner Mongolia Mental Health Center, Hohhot, Inner Mongolia, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Depression remains a leading global health issue, with many patients failing to respond to traditional treatments. Emerging research links depression to gut microbiota dysbiosis, suggesting a role for microbiota-based interventions. This study explores the effects of Mongolian Andai therapy on gut microbiota and metabolites in depressed patients. Methods: Twenty patients with depression underwent 8 weeks of Andai therapy. Gut microbiota was analyzed using 16S rRNA sequencing, and blood metabolites were analyzed through metabolomics. Bioinformatic analyses, including PCA and KEGG enrichment, were performed to identify treatment-related changes. Results: Andai therapy resulted in significant changes in gut microbiota, including an increase in Conclusion: Andai therapy modulates gut microbiota and metabolic pathways related to depression, suggesting its potential as a complementary treatment. Larger studies and multi-omics approaches are necessary to explore these mechanisms further.

Indexed as

Andai therapydepressiongut microbiotametabolomicstreatment response

Identifiers

PMID42318195

DOI10.3389/fnins.2026.1743844

PMCPMC13272016

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