Dietary antioxidant intake and health-related quality of life.

Purpose: Few studies have examined nutrient-specific antioxidant intake and health-related quality of life (HRQoL) in Middle Eastern populations. This cross-sectional study was conducted to investigate the association between dietary antioxidant intakes and HRQoL among Iranian adults. Methods: Using data from the Tehran Lipid and Glucose Study, we included 1,766 adults (54.3% female) with a mean age of 39.4 ± 13.2 years. Dietary intake of antioxidant vitamins and minerals-including vitamin A, vitamin C, vitamin E, zinc (Zn), magnesium (Mg), selenium (Se), manganese (Mn), and β-carotene-was assessed using a Food Frequency Questionnaire. HRQoL was evaluated using a validated questionnaire. General linear models were used to assess the associations between individual antioxidant nutrients and HRQoL scores. Results: In women, higher vitamin A intake was significantly associated with greater HRQoL and its dimensions, except for "role physical," "bodily pain," and "vitality." Increased vitamin C intake was associated with better "physical function," "role physical," and the physical component summary (PCS) in women ( Conclusions: The study highlights that increased consumption of vitamins A and C, Mg, and Se is associated wtih better HRQoL, especially in women, with significant improvements in physical HRQoL. Supplementary Information: The online version contains supplementary material available at 10.1007/s40200-026-01978-5.