Evidence map›Paper›PMID 42318178›Full record

ArticlePNAS nexus2026

Physics-informed differentiable solvers for learning parametric solution manifolds in heterogeneous physical systems.

Milad Panahi, Giovanni Michele Porta, Monica Riva, Alberto Guadagnini

Abstract read
In one paragraph

Article in PNAS nexus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Milad PanahiDipartimento di Ingegneria Civile e Ambientale, Politecnico di Milano, Piazza L. da Vinci 32, Milano 20133, Italy.ORCID https://orcid.org/0000-0002-8776-5297
Giovanni Michele PortaDipartimento di Ingegneria Civile e Ambientale, Politecnico di Milano, Piazza L. da Vinci 32, Milano 20133, Italy.ORCID https://orcid.org/0000-0002-0636-373X
Monica RivaDipartimento di Ingegneria Civile e Ambientale, Politecnico di Milano, Piazza L. da Vinci 32, Milano 20133, Italy.ORCID https://orcid.org/0000-0002-7304-4114
Alberto GuadagniniDipartimento di Ingegneria Civile e Ambientale, Politecnico di Milano, Piazza L. da Vinci 32, Milano 20133, Italy.ORCID https://orcid.org/0000-0003-3959-9690

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Quantifying parametric uncertainty in partial differential equations is a central challenge to our ability to model the behavior of heterogeneous systems. This challenge is relevant to a variety of fundamental and application-oriented implications where system properties exhibit significant (and often uncertain) spatial heterogeneity. We address this by reformulating a physics-informed neural network as a differentiable solver that learns the continuous solution manifold for steady-state Darcy flow. Our framework requires only a single training run, circumventing the need for costly retraining for each new parameter instance. The approach is demonstrated through two representations of spatially heterogeneous hydraulic conductivity fields: a direct analytical form and a novel data-driven formulation resting on an autoencoder to create a low-dimensional latent encoding. A key innovation is the integration of the differentiable decoder into the physics-informed loss function, enabling on-the-fly reconstruction of complex conductivity fields. The approach yields accurate, mass-conserving flow solutions and supports efficient uncertainty quantification, providing a general methodology for physics-constrained data-driven modeling of heterogeneous systems.

Indexed as

Darcy flowdifferentiable physicsparameterized PDEsphysics-informed neural networksuncertainty quantification

Identifiers

PMID42318178
PMCPMC13275013

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.