ArticlePNAS nexus2026
Physics-informed differentiable solvers for learning parametric solution manifolds in heterogeneous physical systems.
Article in PNAS nexus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Quantifying parametric uncertainty in partial differential equations is a central challenge to our ability to model the behavior of heterogeneous systems. This challenge is relevant to a variety of fundamental and application-oriented implications where system properties exhibit significant (and often uncertain) spatial heterogeneity. We address this by reformulating a physics-informed neural network as a differentiable solver that learns the continuous solution manifold for steady-state Darcy flow. Our framework requires only a single training run, circumventing the need for costly retraining for each new parameter instance. The approach is demonstrated through two representations of spatially heterogeneous hydraulic conductivity fields: a direct analytical form and a novel data-driven formulation resting on an autoencoder to create a low-dimensional latent encoding. A key innovation is the integration of the differentiable decoder into the physics-informed loss function, enabling on-the-fly reconstruction of complex conductivity fields. The approach yields accurate, mass-conserving flow solutions and supports efficient uncertainty quantification, providing a general methodology for physics-constrained data-driven modeling of heterogeneous systems.
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