Evidence map›Paper›PMID 42318156›Full record

ArticlemicroPublication biology2026

Minoxidil May be a Partial Agonist of Estrogen Receptor Alpha.

Reem Elzaghir, Kailah C Collins, Alaa Abdulshafi, Mostafa Ismail, Nora Asleh, Maya Saeed, Diego E Galarza-Ramirez, Eduardo Valladares, Ashlee Lewis, Samantha Mena and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in microPublication biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Reem ElzaghirDepartment of Chemistry & Biochemistry, University of Detroit Mercy, Detroit, MI, US.
Kailah C CollinsDepartment of Chemistry & Biochemistry, University of Detroit Mercy, Detroit, MI, US.
Alaa AbdulshafiDepartment of Chemistry & Biochemistry, University of Detroit Mercy, Detroit, MI, US.
Mostafa IsmailDepartment of Chemistry & Biochemistry, University of Detroit Mercy, Detroit, MI, US.
Nora AslehDepartment of Chemistry & Biochemistry, University of Detroit Mercy, Detroit, MI, US.
Maya SaeedDepartment of Chemistry & Biochemistry, University of Detroit Mercy, Detroit, MI, US.
Diego E Galarza-RamirezDepartment of Chemistry & Biochemistry, University of Detroit Mercy, Detroit, MI, US.
Eduardo ValladaresDepartment of Chemistry & Biochemistry, University of Detroit Mercy, Detroit, MI, US.
Ashlee LewisDepartment of Chemistry & Biochemistry, University of Detroit Mercy, Detroit, MI, US.
Samantha MenaDepartment of Chemistry & Biochemistry, University of Detroit Mercy, Detroit, MI, US.
Antonina PizzoDepartment of Chemistry & Biochemistry, University of Detroit Mercy, Detroit, MI, US.
Antonela ShytiDepartment of Chemistry & Biochemistry, University of Detroit Mercy, Detroit, MI, US.
Nicole A NajorDepartment of Biology, University of Detroit Mercy, Detroit, MI, US.
Marwa K Abdel LatifDepartment of Chemistry & Biochemistry, University of Detroit Mercy, Detroit, MI, US.
Mara R LivezeyDepartment of Chemistry & Biochemistry, University of Detroit Mercy, Detroit, MI, US.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Minoxidil (MX) is a common treatment for androgenetic alopecia (AGA). While there are many proposed mechanisms through which MX may increase hair growth, a clear connection to sex-hormone pathways has yet to be established. With recent evidence suggesting that MX may directly bind to Androgen Receptor (AR) and act as an anti-androgen, we investigated whether MX might also exhibit estrogenic activity. Estrogen-dependent cell lines, tryptophan emission, and computational docking were used to probe the possible Estrogen Receptor α (ERα) agonist activity of MX. Preliminary results suggest MX may be a partial agonist of ERα.

Identifiers

PMID42318156
PMCPMC13273740

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.