ArticlemicroPublication biology2026
Klf2 as a potential regulator of the signaling Enos/Nhe3/Nherf2 axis in the early adaptive response to MSG-induced renal injury.
Article in microPublication biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Oxidative stress-induced renal impairment can result from an overconsumption of monosodium glutamate (MSG). In this context, we analyzed the expression of Krüpple-like factors (KLFs) to identify regulators of ionic homeostasis. Our results suggested that Klf2 is key in regulating the Enos/Nhe3/Nherf2 axis; after identifying putative binding sites with a confidence threshold of over 96%. Suggesting, an early adaptative mechanism in which Klf2 modulates ion transport and vascular function, protecting the kidney from hemodynamic alterations. Thus, Klf2 emerges as an essential regulatory node against nephrotoxicity.
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