ArticleFrontiers in cardiovascular medicine2026
Nonlinear association of HbA1c/HDL-C ratio with heart failure in adults: a large cross-sectional study.
Article in Frontiers in cardiovascular medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Heart failure (HF) remains a leading cause of morbidity and mortality worldwide. The HbA1c/HDL-C ratio, a novel composite biomarker reflecting glycemic control and lipid metabolism, may be associated with HF risk, but its specific relationship remains underexplored. This study aimed to investigate the association between the HbA1c/HDL-C ratio and HF. Methods: We utilized samples from two sources: 1,360 inpatients from a cardiology department in 2020 and 101,316 participants from the National Health and Nutrition Examination Survey ( Results: In an analysis of the NHANES sample including 48,922 participants, 1,598 individuals were identified as having HF, corresponding to a prevalence of 3.27%. In a separate clinical sample of 584 participants, 132 had HF, yielding an overall prevalence of 22.60%. After full adjustment, the HbA1c/HDL-C ratio demonstrated a consistent positive association with HF risk in both the NHANES sample (OR =1.07, 95% CI: 1.01-1.14; Conclusion: This study found a nonlinear positive association between the HbA1c/HDL-C ratio and the risk of HF, identifying key threshold values.
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