Evidence map›Paper›PMID 42318138›Full record

ArticleMolecular therapy. Advances2026

Efficacy and safety of SENS-501, a dual-AAV otoferlin gene therapy, for DFNB9 congenital deafness.

Rafik Boudra, Guillaume Olivier, Christophe Tran Van Ba, Lise Barrot, Pierre Rambeau, Charlène Vaux, Sandra Pierredon, Charlène Joséphine, Anaïs Pages, Audrey Broussy and 17 more

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular therapy. Advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

27 authors.

Rafik BoudraSensorion, 375 Rue Du Professeur Joseph Blayac, 34080 Montpellier, France, 21 Rue de La Boétie, 75008 Paris, France.
Guillaume OlivierSensorion, 375 Rue Du Professeur Joseph Blayac, 34080 Montpellier, France, 21 Rue de La Boétie, 75008 Paris, France.
Christophe Tran Van BaSensorion, 375 Rue Du Professeur Joseph Blayac, 34080 Montpellier, France, 21 Rue de La Boétie, 75008 Paris, France.
Lise BarrotSensorion, 375 Rue Du Professeur Joseph Blayac, 34080 Montpellier, France, 21 Rue de La Boétie, 75008 Paris, France.
Pierre RambeauSensorion, 375 Rue Du Professeur Joseph Blayac, 34080 Montpellier, France, 21 Rue de La Boétie, 75008 Paris, France.
Charlène VauxSensorion, 375 Rue Du Professeur Joseph Blayac, 34080 Montpellier, France, 21 Rue de La Boétie, 75008 Paris, France.
Sandra PierredonSensorion, 375 Rue Du Professeur Joseph Blayac, 34080 Montpellier, France, 21 Rue de La Boétie, 75008 Paris, France.
Charlène JoséphineSensorion, 375 Rue Du Professeur Joseph Blayac, 34080 Montpellier, France, 21 Rue de La Boétie, 75008 Paris, France.
Anaïs PagesSensorion, 375 Rue Du Professeur Joseph Blayac, 34080 Montpellier, France, 21 Rue de La Boétie, 75008 Paris, France.
Audrey BroussySensorion, 375 Rue Du Professeur Joseph Blayac, 34080 Montpellier, France, 21 Rue de La Boétie, 75008 Paris, France.
Anne-Gabrielle HarrusSensorion, 375 Rue Du Professeur Joseph Blayac, 34080 Montpellier, France, 21 Rue de La Boétie, 75008 Paris, France.
Selma DadakSensorion, 375 Rue Du Professeur Joseph Blayac, 34080 Montpellier, France, 21 Rue de La Boétie, 75008 Paris, France.
Pauline LiaudetSensorion, 375 Rue Du Professeur Joseph Blayac, 34080 Montpellier, France, 21 Rue de La Boétie, 75008 Paris, France.
Géraldine H PetitSensorion, 375 Rue Du Professeur Joseph Blayac, 34080 Montpellier, France, 21 Rue de La Boétie, 75008 Paris, France.
Ophélie PoujadeSensorion, 375 Rue Du Professeur Joseph Blayac, 34080 Montpellier, France, 21 Rue de La Boétie, 75008 Paris, France.
Jérôme NevouxUniversité Paris Saclay, Institut de L'Audition, Paris, France, 63, Rue de Charenton, 75012 Paris, France.
Ghizlene LahlouAPHP, Sorbonne Université, GHU Pitié-Salpêtrière, Service D'ORL et Implants Auditifs, Paris, France.
Natalie LoundonCentre de Recherche en Audiologie (CREA), Hôpital Necker-Enfants Malades, AP-HP, Paris, France.
Christine Le BecSensorion, 375 Rue Du Professeur Joseph Blayac, 34080 Montpellier, France, 21 Rue de La Boétie, 75008 Paris, France.
Emilie BousquetSensorion, 375 Rue Du Professeur Joseph Blayac, 34080 Montpellier, France, 21 Rue de La Boétie, 75008 Paris, France.
Baptiste PlionUniversité Paris Saclay, Institut de L'Audition, Paris, France, 63, Rue de Charenton, 75012 Paris, France.
Stéphanie FilipeSensorion, 375 Rue Du Professeur Joseph Blayac, 34080 Montpellier, France, 21 Rue de La Boétie, 75008 Paris, France.
Marie-José LecomteUniversité Paris Saclay, Institut de L'Audition, Paris, France, 63, Rue de Charenton, 75012 Paris, France.
Saaid SafieddineUniversité Paris Saclay, Institut de L'Audition, Paris, France, 63, Rue de Charenton, 75012 Paris, France.
Christine PetitUniversité Paris Cité, Institut Pasteur, AP-HP, INSERM, CNRS, Fondation Pour L'Audition, Institut de L'Audition, IHU ReConnect, 75012 Paris, France.
Arnaud P J GieseSensorion, 375 Rue Du Professeur Joseph Blayac, 34080 Montpellier, France, 21 Rue de La Boétie, 75008 Paris, France.
Laurent DesireSensorion, 375 Rue Du Professeur Joseph Blayac, 34080 Montpellier, France, 21 Rue de La Boétie, 75008 Paris, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Congenital sensorineural hearing loss heavily impacts patients' lives and their ability to communicate. Non-syndromic autosomal recessive deafness 9 (DFNB9), caused by mutations in

Indexed as

AAV biodistributionAudiogeneDFNB9dual-AAVgene therapyGLP toxicity studieshereditary hearing lossOTOFSENS-501

Identifiers

PMID42318138
PMCPMC13272531

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.