Evidence map›Paper›PMID 42318071›Full record

ArticlebioRxiv : the preprint server for biology2025

A Retinoic Acid Autoregulatory Loop Governing Prefrontal-Motor Arealization.

Lin Yang, Mikihito Shibata, Saejeong Park, Yuting Liu, Iva Salamon, Jia Liu, Suel-Kee Kim, Akemi Shibata, Ashley Deveau-French, Xoel Mato Blanco and 8 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

18 authors.

Lin YangDepartment of Neuroscience, Yale School of Medicine, New Haven, CT, USA.ORCID 0000-0003-2277-5440
Mikihito ShibataDepartment of Neuroscience, Yale School of Medicine, New Haven, CT, USA.ORCID 0009-0008-5588-4583
Saejeong ParkDepartment of Neuroscience, Yale School of Medicine, New Haven, CT, USA.ORCID 0000-0002-0926-8076
Yuting LiuDepartment of Neuroscience, Yale School of Medicine, New Haven, CT, USA.ORCID 0000-0001-8380-2882
Iva SalamonDepartment of Neuroscience, Yale School of Medicine, New Haven, CT, USA.ORCID 0000-0003-3817-1983
Jia LiuDepartment of Neuroscience, Yale School of Medicine, New Haven, CT, USA.
Suel-Kee KimDepartment of Neuroscience, Yale School of Medicine, New Haven, CT, USA.ORCID 0000-0003-0240-9304
Akemi ShibataDepartment of Neuroscience, Yale School of Medicine, New Haven, CT, USA.ORCID 0009-0006-6761-691X
Ashley Deveau-FrenchDepartment of Neuroscience, Yale School of Medicine, New Haven, CT, USA.ORCID 0009-0006-2655-8602
Xoel Mato BlancoDepartment of Neuroscience, Yale School of Medicine, New Haven, CT, USA.ORCID 0000-0003-2155-9922
Suxia BaiYale Genome Editing Center, Yale School of Medicine, New Haven, CT, USA.ORCID 0009-0001-5139-9758
Timothy NottoliYale Genome Editing Center, Yale School of Medicine, New Haven, CT, USA.ORCID 0000-0002-2218-5590
Xiaojun XingYale Genome Editing Center, Yale School of Medicine, New Haven, CT, USA.
Narjes RohaniInstitute of Developmental and Regenerative Medicine, Department of Paediatrics, University of Oxford, Oxford, UK.ORCID 0000-0003-4441-9359
Stephan J SandersInstitute of Developmental and Regenerative Medicine, Department of Paediatrics, University of Oxford, Oxford, UK.ORCID 0000-0001-9112-5148
Rothem KovnerDepartment of Neuroscience, Yale School of Medicine, New Haven, CT, USA.ORCID 0000-0002-3874-8888
Kartik PattabiramanDepartment of Neuroscience, Yale School of Medicine, New Haven, CT, USA.ORCID 0000-0002-3924-426X
Nenad SestanDepartment of Neuroscience, Yale School of Medicine, New Haven, CT, USA.ORCID 0000-0003-0966-9619

Funding

Functional Genomics of Human Brain DevelopmentP50MH106934 · NIMH · YALE UNIVERSITY · PI SESTAN, NENAD · 2014 to 2019
$7.9M
1/2 Cell Type and Region-Specific Regulatory Networks in Human Brain Development and DisordersU01MH116488 · NIMH · YALE UNIVERSITY · PI SESTAN, NENAD · 2018 to 2022
$6.5M
Heterogeneity of Forebrain Neural PrecursorsR01NS095654 · NINDS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI HAYDAR, TARIK F, SESTAN, NENAD · 2015 to 2019
$3.4M
1/3 Integrative Genomic Analysis of Human Brain Development and AutismR01MH110926 · NIMH · YALE UNIVERSITY · PI SESTAN, NENAD · 2016 to 2019
$3.2M
Association of gene expression and brain connectivity in human cerebral cortex development and adulthoodR01MH129981 · NIMH · CHILDREN'S HOSP OF PHILADELPHIA · PI HUANG, HAO · 2022 to 2025
$1.8M
4/4 - The Autism Sequencing Consortium: Discovering autism risk genes and how they impact core features of the disorderR01MH129751 · NIMH · UNIVERSITY OF OXFORD · PI Stephan Sanders · 2022 to 2026
$1.4M
2/2 - Identification and Validation of Expression Quantitative Trait Loci (eQTLs) in discrete cell types across human brain developmentR01MH122681 · NIMH · UNIVERSITY OF OXFORD · PI SANDERS, STEPHAN · 2023 to 2025
$1.3M
2/2 - Identification and Validation of Expression Quantitative Trait Loci (eQTLs) in discrete cell types across human brain developmentU01MH122681 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SANDERS, STEPHAN · 2021 to 2022
$1.2M
NIMH NIH HHS P50 MH106934NIMH NIH HHS R01 MH110926NIMH NIH HHS R01 MH122681NIMH NIH HHS R01 MH129751NIMH NIH HHS R01 MH129981NIMH NIH HHS U01 MH116488NIMH NIH HHS U01 MH122681NINDS NIH HHS R01 NS095654
6 · The paper itself

Abstract

The frontal lobe comprises the prefrontal association cortex (PFC), which supports complex cognition and goal-directed behavior, and the motor cortex (MC), which executes movement. A hallmark of primate brain evolution is PFC expansion accompanied by a posterior displacement of the MC. Retinoic acid (RA) signaling has emerged as a key regulator of PFC specification and expansion. However, the mechanisms that spatially confine RA signaling within the developing PFC, and the downstream RA-responsive gene networks, remain poorly understood. Here we defined an RA-associated gene regulatory network (RA-GRN) in the developing human PFC and identified

Identifiers

PMID42318071
PMCPMC13274254

What OpenQuestion holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.