Evidence map›Paper›PMID 42318054›Full record

ArticleBioactive materials2026

Unconventional auricular reconstruction using controlled scaffold buckling and chondrogenic cocktail containing muscle-derived cells.

Na Huang, Shui Kwong John Lee, Ka Ho Kenneth Lee, Chunyi Wen, Yun Chang, Ming Zhang, Cheng Dong, Chuanbin Mao, Dan Michelle Wang, Dai Fei Elmer Ker

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioactive materials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Na HuangInstitute for Tissue Engineering and Regenerative Medicine, Faculty of Medicine, The Chinese University of Hong Kong, China.
Shui Kwong John LeeDepartment of Otorhinolaryngology, Head & Neck Surgery, Faculty of Medicine, The Chinese University of Hong Kong, China.
Ka Ho Kenneth LeeOccam Biosciences, Prospect II, Dundee Technology Park, Scotland, United Kingdom.
Chunyi WenDepartment of Biomedical Engineering, Faculty of Engineering, The Hong Kong Polytechnic University, China.
Yun ChangDepartment of Biomedical Engineering, Faculty of Engineering, The Hong Kong Polytechnic University, China.
Ming ZhangDepartment of Biomedical Engineering, Faculty of Engineering, The Hong Kong Polytechnic University, China.
Cheng DongDepartment of Biomedical Engineering, Faculty of Engineering, The Hong Kong Polytechnic University, China.
Chuanbin MaoDepartment of Biomedical Engineering, Faculty of Engineering, The Chinese University of Hong Kong, China.
Dan Michelle WangInstitute for Tissue Engineering and Regenerative Medicine, Faculty of Medicine, The Chinese University of Hong Kong, China.
Dai Fei Elmer KerDepartment of Biomedical Engineering, Faculty of Engineering, The Hong Kong Polytechnic University, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tissue engineered auricles face challenges such as subpar graft mechanical robustness, insufficient stem/progenitor cells, and unidentified factors that specifically promote elastic cartilage. To tackle these, we developed resilient and bioactive 3D-printed scaffolds using two unconventional concepts, including controlled buckling compliant lattices for mechanical resilience and muscle-derived stem/progenitor cells (MDSCs) with defined biochemical factors for facile elastic cartilage-like regeneration. Our functionally graded design reduced stress by 63.1% relative to other graded designs, which was validated by finite element analysis and high-magnitude compressive testing. Notably, 91.7% of scaffolds remained undamaged in stark contrast to 100% failure for clinically-used MEDPOR® and 76.5% failure for other graded scaffolds. Further, we developed an elastic auricular regenerative cocktail (EARc) comprised of abundantly available MDSCs and elastic cartilage-specific biochemical factors.

Indexed as

3D-printingAuricular tissue engineeringBucklingCompliant latticesElastic chondrogenesisFunctionally graded scaffoldsMuscle-derived cells

Identifiers

PMID42318054
PMCPMC13273865

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.