Evidence map›Paper›PMID 42318052›Full record

ArticleBioactive materials2026

High-throughput synthesis of zinc-functionalized bio-ceramics propels the rational design of bone implants.

Hao Huang, Bingjun Zhang, Shaojie Zhu, Dongbiao Chang, Liwen Yang, Jinsheng Li, Lei Qiang, Bobo Jiang, Ruiquan Li, Xiong Lu and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioactive materials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Hao HuangInstitute of Biomedical Engineering, College of Medicine, Southwest Jiaotong University, Chengdu, 610031, China.
Bingjun ZhangSuzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences, Suzhou, 215163, China.
Shaojie ZhuDepartment of Orthopaedic Surgery, Children's Hospital of Nanjing Medical University, Nanjing, 210008, China.
Dongbiao ChangInstitute of Biomedical Engineering, College of Medicine, Southwest Jiaotong University, Chengdu, 610031, China.
Liwen YangInstitute of Biomedical Engineering, College of Medicine, Southwest Jiaotong University, Chengdu, 610031, China.
Jinsheng LiInstitute of Biomedical Engineering, College of Medicine, Southwest Jiaotong University, Chengdu, 610031, China.
Lei QiangInstitute of Biomedical Engineering, College of Medicine, Southwest Jiaotong University, Chengdu, 610031, China.
Bobo JiangSichuan Taikang Hospital, Chengdu, 610031, China.
Ruiquan LiSchool of Engineering, Westlake University, Hangzhou, 310030, China.
Xiong LuInstitute of Biomedical Engineering, College of Medicine, Southwest Jiaotong University, Chengdu, 610031, China.
Tailin GuoInstitute of Biomedical Engineering, College of Medicine, Southwest Jiaotong University, Chengdu, 610031, China.
Xin ChenDepartment of Laboratory Medicine, The Third People's Hospital of Chengdu/ Affiliated Hospital of Southwest Jiaotong University, Chengdu, 610031, China.
Pengfei ZhengDepartment of Orthopaedic Surgery, Children's Hospital of Nanjing Medical University, Nanjing, 210008, China.
Jie WengInstitute of Biomedical Engineering, College of Medicine, Southwest Jiaotong University, Chengdu, 610031, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Endowing basic ceramics with functional elements effectively improves their physicochemical and biological properties. Nevertheless, these properties are strongly influenced by particle size, thermodynamic and kinetic conditions, and lattice structure. Such complexity requires extensive trial-and-error optimization, greatly limiting materials development efficiency. To overcome this challenge, we established a high-throughput synthesis platform that enables precise control over the morphologies and crystalline phases of zinc-doped calcium phosphate (Zn-CaPs) by independently manipulating 18 reaction times and 48 reaction temperatures, facilitating the execution of up to 144 experiments concurrently. The potential mechanisms by which system concentration, zinc/calcium ratio, pH, reaction time, temperature, and binary solvent concentration influence the crystallization of Zn-CaPs were investigated. The Zn-CaPs exhibited remarkable cytocompatibility, osteogenic bioactivity, and antibacterial properties. A porous scaffold (Zn-CaPS) fabricated from Zn-CaPs demonstrated a strength of over twice that of a commercial CaPs scaffold. Notably, after 6 and 12 weeks of implantation in a rabbit femoral defect model, the Zn-CaP scaffold achieved over 4-fold and 2-fold higher BV/TV than the control and commercial CaPs scaffolds, respectively. This work develops an innovative material genome framework for high-performance ion-doped bioceramics. It integrates high-throughput design, synthesis, and performance evaluation to accelerate R&D and yield socioeconomic benefits.

Indexed as

Calcium phosphateHigh-performanceHigh-throughputMaterial genome

Identifiers

PMID42318052
PMCPMC13273695

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LicenceCC BY-NC-ND
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.