Epigenetic Aging and Cognitive Performance in General and Psychiatric Populations: A Systematic Review and Narrative Synthesis.

Natan Yusupov, Julia Fietz, Vera N Karlbauer, Isabel Maurus, Peter Falkai, Elisabeth B Binder

Abstract readReview

In one paragraph

Review in Biological psychiatry global open science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Natan YusupovDepartment Genes and Environment, Max Planck Institute of Psychiatry, Munich, Germany.

Julia FietzDepartment of Psychiatry and Psychotherapy, University Hospital, Ludwig Maximilian University of Munich, Munich, Germany.

Vera N KarlbauerDepartment Genes and Environment, Max Planck Institute of Psychiatry, Munich, Germany.

Isabel MaurusDepartment of Psychiatry and Psychotherapy, University Hospital, Ludwig Maximilian University of Munich, Munich, Germany.

Peter FalkaiDepartment of Psychiatry and Psychotherapy, University Hospital, Ludwig Maximilian University of Munich, Munich, Germany.

Elisabeth B BinderDepartment Genes and Environment, Max Planck Institute of Psychiatry, Munich, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Epigenetic aging and age-related cognitive decline both show substantial variability across individuals. While a potential link between the two is increasingly being studied in both general and psychiatric populations, a systematic review has not yet been performed. This review summarizes the state of the current literature as well as critical evaluation and suggestions for future research. A literature search (October 31, 2024) identified original peer-reviewed studies examining epigenetic aging and cognitive function in general and/or psychiatric populations following a preregistered protocol (PROSPERO Registration No. CRD42024608024). Other article types or non-English language works were excluded. A total of 57 observational studies (

Indexed as

CognitionCognitive declineEpigenetic ageEpigenetic clocksPsychiatrySystematic review

Identifiers

PMID42318041

DOI10.1016/j.bpsgos.2026.100726

PMCPMC13273795

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.