ReviewCureus2026
Potential of Glucagon-Like Peptide-1 (GLP-1) Receptor Agonists in Mitigating Metabolic Side Effects Associated With Clozapine or Olanzapine Therapy: A Literature Review.
Review in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Clozapine and Olanzapine can cause severe metabolic side effects, increasing cardiovascular risk. Glucagon-like peptide-1 (GLP-1) receptor agonists, primarily approved for use in patients with type 2 diabetes, may counter these effects by promoting weight loss, improving glucose metabolism, and enhancing cardiovascular health, offering a promising approach for managing antipsychotic-related metabolic complications. We conducted a literature review using the search terms "clozapine OR olanzapine AND GLP-1 agonist," "schizophrenia AND GLP-1 agonist," "antipsychotic AND GLP-1 agonist," and "psychosis AND GLP-1 agonist" on PubMed and Google Scholar. This search initially yielded 172 articles. We focused on clinical trials or case reports investigating the use of GLP-1 agonists in conjunction with Olanzapine or Clozapine. Our final selection included two clinical trial studies, one case report, and a retrospective study. In a case report, a schizophrenic patient on Clozapine treated with liraglutide experienced a reduction in glycated hemoglobin (HbA1c ), from 10% to 6.5% over 14 months, along with a total weight loss of 7.7 kg (8.7% body weight reduction) after two years, and decreased insulin requirements. In a retrospective study reviewing 16 obese patients with schizophrenia treated with liraglutide, of whom 14 were on Clozapine, significant reductions in body weight, waist circumference, body mass index (BMI), and plasma glucose levels were observed over 16 weeks (
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.