Evidence map›Paper›PMID 42317814›Full record

ArticleAMIA Joint Summits on Translational Science proceedings. AMIA Joint Summits on Translational Science2026

Exploring the Utility of MALDI-TOF Mass Spectrometry and Antimicrobial Resistance in Hospital Outbreak Detection.

Chang Liu, Jieshi Chen, Alexander J Sundermann, Kathleen Shutt, Marissa P Griffith, Lora Lee Pless, Lee H Harrison, Artur W Dubrawski

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In one paragraph

Article in AMIA Joint Summits on Translational Science proceedings. AMIA Joint Summits on Translational Science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Chang LiuAuton Lab, Carnegie Mellon University, Pittsburgh, Pennsylvania, USA.
Jieshi ChenAuton Lab, Carnegie Mellon University, Pittsburgh, Pennsylvania, USA.
Alexander J SundermannMicrobial Genomic Epidemiology Laboratory, Center for Genomic Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Kathleen ShuttMicrobial Genomic Epidemiology Laboratory, Center for Genomic Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Marissa P GriffithMicrobial Genomic Epidemiology Laboratory, Center for Genomic Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Lora Lee PlessMicrobial Genomic Epidemiology Laboratory, Center for Genomic Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Lee H HarrisonMicrobial Genomic Epidemiology Laboratory, Center for Genomic Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Artur W DubrawskiAuton Lab, Carnegie Mellon University, Pittsburgh, Pennsylvania, USA.

Funding

Enhanced Detection System for Healthcare-Associated Transmission of InfectionR01AI127472 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI HARRISON, LEE H · 2016 to 2025
$7.6M
NIAID NIH HHS R01 AI127472
6 · The paper itself

Abstract

Accurate and timely identification of hospital outbreak clusters is crucial for preventing the spread of infections that have epidemic potential. While assessing pathogen similarity through whole genome sequencing (WGS) is considered the gold standard for outbreak detection, its high cost and lengthy turnaround time preclude routine implementation in clinical laboratories. We explore the utility of two rapid and cost-effective alternatives to WGS, matrix-assisted laser desorption ionization-time of flight (MALDI-TOF) mass spectrometry and antimicrobial resistance (AR) patterns. We develop a machine learning framework that extracts informative representations from MALDI-TOF spectra and AR patterns for outbreak detection and explore their fusion. Through multi-species analyses, we demonstrate that in some cases MALDI-TOF and AR have the potential to reduce reliance on WGS, enabling more accessible and rapid outbreak surveillance.

Identifiers

PMID42317814
PMCPMC13274314

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.