ReviewiScience2026
Frailty syndrome in older adults: Research advances and management strategies.
Review in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Modifiable factors associated with frailty among indigenous older adults in southern Taiwan: a community-based cross-sectional study.Frontiers in public health · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Frailty represents a critical clinical syndrome characterized by diminished physiological reserve and heightened vulnerability to stressors, serving as a robust predictor of disability and mortality in the aging population. This review comprehensively synthesizes current evidence regarding the biological mechanisms, evolving assessment tools, and evidence-based management strategies for frailty. Complex multisystem dysregulation is identified as the primary driver of this syndrome, with a particular focus on metabolic-immune imbalances and muscle-mitochondrial axis dysfunction. While traditional clinical assessment models remain diagnostic staples, multi-omics profiling and digital biomarkers, including those derived from wearable sensors, are emerging as transformative tools for earlier and more precise risk stratification. Regarding clinical translation, multimodal interventions that integrate resistance exercise, nutritional optimization, and polypharmacy management constitute the cornerstone of current care. However, the future of geriatric medicine necessitates a paradigm shift beyond descriptive diagnosis. Ultimately, mechanism-driven precision interventions and the integration of digital health technologies are proposed to not merely manage frailty but to quantify and enhance systemic resilience for healthy longevity.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.