ReviewiScience2026
Radiotherapy, EMP and dormancy in TME: An integrated perspective on tumor microenvironments and long-term relapse.
Review in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Radiotherapy (RT) remains one of the most common modalities for curative treatment, with most cancer patients receiving RT during their treatment periods. Although there have been significant improvements in local targeting, local and distant recurrences after RT still remain a major clinical challenge. Dormant tumor cells, which are characterized by quiescent cells, are a potential driver of local recurrence and metastasis after RT. Epithelial-mesenchymal plasticity (EMP) is a central mechanism that allows disseminated tumor cells (DTCs) to enter a dormant state and reawaken to form recurrences years later. This review summarizes current knowledge of the molecular relationship between RT, EMP, and metastatic dormancy. We discuss the possibility whether RT modulates metastasis and dormancy. Ultimately, we propose promising therapeutic strategies to block RT-mediated metastasis and prevent long-term relapse in distant organs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.