ArticleFrontiers in pediatrics2026
Low levels of the protein TRAIL are associated with illness severity in children with suspected infection.
Article in Frontiers in pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL) has a potential role in the immune response to infections. This study investigated the association between serum TRAIL levels and illness severity in children with suspected infection. Methods: A retrospective Results: The analysis included 104 children, with 52 children in each TRAIL group. Children with TRAIL levels ≤40 pg/mL had longer hospitalization duration (4.06 ± 3.5 days vs. 2.50 ± 3.5 days, Discussion: Lower serum TRAIL levels in children were associated with more severe illness, as evidenced by extended hospital stays, increased antibiotic use, and more severe clinical presentations. These findings suggest an association between low TRAIL levels and illness severity, although differences in infection etiology between groups should be considered.
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