ReviewBiophysical reviews2026
Insights from single-molecule force spectroscopy into chromatin topology.
Review in Biophysical reviews, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The organization of DNA into chromatin within the eukaryotic nucleus represents one of the most intricate forms of biological packaging. This organization is inherently hierarchical, spanning multiple length scales: from DNA wrapping around histone octamers to form nucleosomes, to the folding of nucleosome arrays and the establishment of higher-order chromatin domains. Understanding how these scales interconnect is essential for explaining how cells regulate gene expression and replicate their genomes. Single-molecule force spectroscopy has provided powerful mechanistic insights into this architecture by enabling direct measurements of the forces that govern chromatin folding and unfolding. These approaches have clarified how chromatin fibers behave under tension and how nucleosome-level interactions contribute to fiber compaction and stability. In this review, we summarize key discoveries enabled by such techniques and discuss emerging opportunities for probing chromatin in increasingly complex and biologically relevant contexts.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.