SynthesisFrontiers in human neuroscience2026
Spinal cord stimulation to manage autonomic dysfunction after spinal cord injury: a systematic review.
Synthesis in Frontiers in human neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Molecular and Cellular Mechanisms of Spinal Cord Stimulation: Linking Dorsal Horn Circuits, Glia, and ECAP-Guided Therapy.International journal of molecular sciences · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Spinal cord injury (SCI) results in severe autonomic dysfunction, across cardiovascular, bladder, bowel and sexual domains, negatively affecting quality of life. Recently, there has been growing interest in the application of spinal cord stimulation (SCS) to restore or modulate autonomic functions in people with SCI. This review systematically evaluated the evidence for spinal cord and/or root stimulation, delivered via epidural (eSCS), transcutaneous (tSCS) spinal cord stimulation, or sacral (posterior) anterior root stimulation (SARS/SPARS) - in managing autonomic dysfunction after SCI. Methods: A systematic search of OVID Medline, OVID Embase, and Web of Science, was completed in September 2024. Eligible studies included adults with SCI (≥18 years old) receiving eSCS, tSCS, or SARS, reporting at least one quantitative autonomic outcome measure. Extracted data were synthesised by autonomic domain (cardiovascular, urinary, bowel, sexual), intervention type (eSCS, tSCS, or SARS) and duration of stimulation (acute vs. chronic). Results: Fifty-seven articles were identified, evaluating eSCS (30 studies, Conclusion: Electrical stimulation of the spinal cord and/or nerve roots is a promising method for modulating or restoring autonomic function after SCI. However, current evidence is based on small cohort or case studies, or retrospective reporting. Larger controlled studies are recommended to establish efficacy and long-term safety, and further mechanistic investigations are required. Systematic review registration: https://www.crd.york.ac.uk/PROSPERO/view/CRD420250621447, identifier PROSPERO (CRD420250621447).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.