Evidence map›Paper›PMID 42317406›Full record

ArticleBJA open2026

Effect of atropine on time to cardiac arrest in hypoxic bradycardia: a randomised cross-over study in a porcine apnoea model.

Tomáš Pařízek, Petr Waldauf, Michal Kalina, Zuzana Kurzová, Irena Odstrčilová, Jan Hunák, Jakub Freml, Radim Dvořák, David Peřan, Alena Vlková and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BJA open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Tomáš PařízekPIGILAB, Department of Anaesthesia and Intensive Care Medicine, Third Faculty of Medicine, Charles University, Prague and University Hospital Kralovske Vinohrady, Prague, Czech Republic.
Petr WaldaufPIGILAB, Department of Anaesthesia and Intensive Care Medicine, Third Faculty of Medicine, Charles University, Prague and University Hospital Kralovske Vinohrady, Prague, Czech Republic.
Michal KalinaFaculty of Medicine in Hradec Kralove, Charles University, Hradec Kralove, Czech Republic.
Zuzana KurzováPIGILAB, Department of Anaesthesia and Intensive Care Medicine, Third Faculty of Medicine, Charles University, Prague and University Hospital Kralovske Vinohrady, Prague, Czech Republic.
Irena OdstrčilováPIGILAB, Department of Anaesthesia and Intensive Care Medicine, Third Faculty of Medicine, Charles University, Prague and University Hospital Kralovske Vinohrady, Prague, Czech Republic.
Jan HunákPIGILAB, Department of Anaesthesia and Intensive Care Medicine, Third Faculty of Medicine, Charles University, Prague and University Hospital Kralovske Vinohrady, Prague, Czech Republic.
Jakub FremlPIGILAB, Department of Anaesthesia and Intensive Care Medicine, Third Faculty of Medicine, Charles University, Prague and University Hospital Kralovske Vinohrady, Prague, Czech Republic.
Radim DvořákPIGILAB, Department of Anaesthesia and Intensive Care Medicine, Third Faculty of Medicine, Charles University, Prague and University Hospital Kralovske Vinohrady, Prague, Czech Republic.
David PeřanPIGILAB, Department of Anaesthesia and Intensive Care Medicine, Third Faculty of Medicine, Charles University, Prague and University Hospital Kralovske Vinohrady, Prague, Czech Republic.
Alena VlkováCentre of Toxicology and Health Safety, National Institute of Public Health, Prague, Czech Republic.
František DuškaPIGILAB, Department of Anaesthesia and Intensive Care Medicine, Third Faculty of Medicine, Charles University, Prague and University Hospital Kralovske Vinohrady, Prague, Czech Republic.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: In profound hypoxia, including 'cannot intubate, cannot oxygenate' (CICO) situations, bradycardia may represent an oxygen-conserving reflex rather than a correctable pathology. We hypothesised that atropine would, by increasing heart rate and myocardial oxygen demand, hasten cardiac arrest in apnoea-induced hypoxic bradycardia. Methods: We performed a randomised, placebo-controlled, cross-over trial in intubated, anaesthetised pigs ( Results: No statistically significant difference in time to cardiac arrest was detected: 142 seconds (95% Confidence interval [CI] 84-199) after atropine Conclusions: In this porcine model of apnoea-induced hypoxic bradycardia, atropine neither delayed cardiac arrest nor improved oxygenation, perfusion, or resuscitation outcomes. Trial registration number: Open Science Framework (OSF), DOI: https://doi.org/10.17605/OSF.IO/492NY.

Indexed as

apnoeaatropinebradycardiacardiac arresthypoxiaswine

Identifiers

PMID42317406
PMCPMC13273852

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.