ReviewFrontiers in molecular biosciences2026
Multifaceted mechanisms by which environmental endocrine-disrupting chemicals promote cancer progression: crosstalk among carcinogenesis, immunity, and metabolic reprogramming: narrative mini-review.
Review in Frontiers in molecular biosciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Molecular Mechanisms of Endocrine-Disrupting Chemicals and Emerging-Pollutant Toxicity in Human Reproduction: From Xenobiotic Exposure to Fertility Impairment and Reproductive Carcinogenesis.International journal of molecular sciences · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Endocrine-disrupting chemicals (EDCs) are ubiquitous and highly persistent environmental contaminants. Human exposure occurs through multiple routes, including dietary ingestion, water consumption, inhalation, and dermal contact, posing sustained health risks characterized by chronic, low-dose, and cumulative mixture exposure. Through interference with endocrine signaling and related biological pathways, EDCs have been implicated in the development and progression of several health outcomes, particularly reproductive, metabolic, neurodevelopmental, and hormone-related disorders. Of particular concern is their involvement in oncogenesis; throughout tumor progression, EDCs facilitate immune dysregulation and metabolic reprogramming via complex interactions across multiple targets and signaling pathways. Elucidating these underlying regulatory mechanisms is imperative for developing robust preventive strategies. This review synthesizes evidence regarding bisphenols, per- and polyfluoroalkyl substances (PFAS), heavy metals, pesticides, phthalates, polychlorinated biphenyls (PCBs), and other emerging pollutants. We specifically highlight their mechanistic roles across three critical domains: carcinogenesis, immune modulation, and metabolic reprogramming. Given the long latency periods, significant inter-individual variability, and synergistic mixture effects associated with EDC exposure, current risk assessments and causal inferences remain constrained. Future research must integrate high-precision exposure science, prospective longitudinal cohorts, and multi-omic mechanistic validation, while incorporating critical developmental windows and mixture-exposure frameworks. Ultimately, such advancements will provide a more reliable evidence base for exposure prevention, regulatory decision-making, and risk stratification and intervention strategies for exposure-related malignancies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.