Evidence map›Paper›PMID 42317357›Full record

ArticleFrontiers in immunology2026

Peripheral cytotoxic immune profiles in hepatobiliary surgical patients.

Zhen Li, Dongping Yu, Lingyong Liu, Qi Zuo, Jiaqi Wang, Xiangjuan Jiao, Zhi Duan, Dong Chen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Zhen Li *Department of Pathology, The First Hospital of Changsha/The Affiliated Changsha Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan, China.
Dongping Yu *Department of Orthopedics, The Third Affiliated Hospital (the First Hospital of Nanchang), Jiangxi Medical College, Nanchang University, Nanchang, China.
Lingyong Liu *Department of Pathology, The First Hospital of Changsha/The Affiliated Changsha Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan, China.
Qi ZuoDepartment of Emergency, The First Hospital of Changsha/The Affiliated Changsha Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan, China.
Jiaqi WangDepartment of Pathology, The First Hospital of Changsha/The Affiliated Changsha Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan, China.
Xiangjuan JiaoDepartment of Pathology, The First Hospital of Changsha/The Affiliated Changsha Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan, China.
Zhi DuanDepartment of Pathology, The First Hospital of Changsha/The Affiliated Changsha Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan, China.
Dong ChenDepartment of Emergency, The First Hospital of Changsha/The Affiliated Changsha Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Perforin and granzyme B are key effector molecules of cytotoxic T lymphocytes (CTLs) and natural killer (NK) cells. Their expression profiles in hepatobiliary surgical patients and the relative contributions of disease-specific versus host factors remain unclear. Methods: In this retrospective cross-sectional study, 245 consecutive hepatobiliary surgical inpatients were enrolled. Six flow cytometric markers (CD3 Results: NK cells showed consistently high cytotoxic marker expression, exceeding T-cell subsets. No significant differences were observed across disease groups, even after age adjustment (all Conclusions: Peripheral cytotoxic marker expression is primarily driven by age rather than disease category in hepatobiliary surgical patients. CD8

Indexed as

Killer Cells, NaturalT-Lymphocytes, CytotoxicAdultAgedBiomarkersCross-Sectional StudiesFemaleGranzymesHumansMaleMiddle AgedPancreatitisPerforinRetrospective StudiesROC CurveBiomarkersGranzymesPerforinacute pancreatitiscytotoxic lymphocytesflow cytometrygranzyme Bimmunosenescenceperforin

Identifiers

PMID42317357
PMCPMC13271926

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.