Evidence map›Paper›PMID 42317326›Full record

ArticleFrontiers in immunology2026

Cell-autonomous co-stimulatory function of membrane-bound CD100 promotes activation and differentiation of HBcAg-specific CD8

Mengxiao Zhao, Liwei Chen, Yuhang Chen, Lu Wang, Xuecheng Yang, Kathrin Sutter, Mengji Lu, Jieliang Chen, Xin Zheng, Dongliang Yang and 2 more

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Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Mengxiao ZhaoDepartment of Infectious Diseases, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Liwei ChenDepartment of Infectious Diseases, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Yuhang ChenDepartment of Infectious Diseases, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Lu WangDepartment of Infectious Diseases, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Xuecheng YangDepartment of Infectious Diseases, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Kathrin SutterInstitute for Virology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
Mengji LuInstitute for Virology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
Jieliang ChenSchool of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai, China.
Xin ZhengDepartment of Infectious Diseases, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Dongliang YangDepartment of Infectious Diseases, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Liang Wang *Department of Urology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Jia Liu *Department of Infectious Diseases, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: CD100/SEMA4D functions as a critical co-stimulatory molecule in T cell responses, existing in both membrane-bound (mCD100) and soluble (sCD100) forms. Previous studies have shown that CD100 enhances CD8 Methods: We examined the impact of CD100 deficiency on the functional phenotype and differentiation of HBcAg-specific CD8 Results: The absence of mCD100 expression significantly decrease HBcAg-specific CD8 Conclusions: Membrane CD100 expressed on resting HBcAg-specific CD8

Indexed as

Antigens, CDCD8-Positive T-LymphocytesCell DifferentiationHepatitis BHepatitis B virusLymphocyte ActivationAnimalsMiceMice, Inbred C57BLMice, KnockoutSemaphorinsSignal TransductionTOR Serine-Threonine KinasesAntigens, CDCD100 antigenSemaphorinsTOR Serine-Threonine KinasesCD8+ T cellscostimulatory molecularhepatitis B virusJAK-STATmembrane-bound CD100NF-κBPI3K-Akt-mTORtransfer

Identifiers

PMID42317326
PMCPMC13272529

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.