Evidence map›Paper›PMID 42317321›Full record

ArticleFrontiers in immunology2026

Co-culture with fibroblasts in stiff 3D scaffolds increases CD54 and CD140a expression on macrophages.

Jennessa Wx Ng, Santosh Trb Rao, Emily H Field, Kaitlyn Ritchie, Mark D Wright, Nicholas P Reynolds, Sean W Cutter, Katrina J Binger

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jennessa Wx NgDepartment of Biochemistry & Chemistry, School of Agriculture, Biomedicine and Environment, La Trobe University, Melbourne, VIC, Australia.
Santosh Trb RaoHolsworth Biomedical Research Centre, Department of Rural Clinical Sciences, La Trobe Rural Health School, La Trobe University, Bendigo, VIC, Australia.
Emily H FieldDepartment of Biology, School of Science, RMIT University, Melbourne, VIC, Australia.
Kaitlyn RitchieDepartment of Biochemistry & Chemistry, School of Agriculture, Biomedicine and Environment, La Trobe University, Melbourne, VIC, Australia.
Mark D WrightDepartment of Immunology & Pathology, Alfred Medical Research and Education Precinct, School of Translational Medicine, Monash University, Melbourne, VIC, Australia.
Nicholas P ReynoldsDepartment of Biochemistry & Chemistry, School of Agriculture, Biomedicine and Environment, La Trobe University, Melbourne, VIC, Australia.
Sean W Cutter *Department of Biochemistry & Chemistry, School of Agriculture, Biomedicine and Environment, La Trobe University, Melbourne, VIC, Australia.
Katrina J Binger *Department of Biochemistry & Chemistry, School of Agriculture, Biomedicine and Environment, La Trobe University, Melbourne, VIC, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Vascular fibrosis is a major contributor to hypertension and cardiovascular disease and is caused by excessive extracellular matrix deposition and tissue stiffening. Macrophages and fibroblasts are key regulators of this process, yet most studies have relied on non-physiological two-dimensional (2D)

Indexed as

FibroblastsIntercellular Adhesion Molecule-1MacrophagesTissue ScaffoldsAnimalsCell CommunicationCell Culture Techniques, Three DimensionalCells, CulturedCoculture TechniquesMiceIntercellular Adhesion Molecule-13D cultureco-culturemacrophage activationmyofibroblastvascular fibrosis

Identifiers

PMID42317321
PMCPMC13272094

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.