Evidence map›Paper›PMID 42317258›Full record

ArticleTherapeutic advances in medical oncology2026

Lineage infidelity in FH-deficient RCC with secondary somatic alterations: a case report and implications for diagnosis and treatment.

Jianping Zhao, Derek B Allison, Giannicola Genovese, Stephanie Rock, Noah Spies, Michael Hensley, Gleb Khegai, Anastasiya Makeeva, Daria Melikhova, Lev Bedniagin and 3 more

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Therapeutic advances in medical oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Jianping ZhaoDepartment of Anatomical Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Derek B AllisonAllison Department of Pathology and Laboratory Medicine, University of Kentucky College of Medicine, Lexington, KY 40536, USA.
Giannicola GenoveseDepartment of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Stephanie RockCaris Life Sciences, Phoenix, AZ, USA.
Noah SpiesCaris Life Sciences, Phoenix, AZ, USA.
Michael HensleyBostonGene Corporation, Waltham, MA, USA.
Gleb KhegaiBostonGene Corporation, Waltham, MA, USA.
Anastasiya MakeevaBostonGene Corporation, Waltham, MA, USA.
Daria MelikhovaBostonGene Corporation, Waltham, MA, USA.
Lev BedniaginBostonGene Corporation, Waltham, MA, USA.
Patrick J HensleyDepartment of Pathology and Laboratory Medicine, University of Kentucky College of Medicine, Lexington, KY, USA.
Zin W MyintMarkey Cancer Center, Lexington, KY, USA.ORCID https://orcid.org/0000-0002-3479-4203
Pavlos MsaouelDepartment of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center Unit 1374, 1155 Pressler St., Houston, TX 77030-3721, USA.ORCID https://orcid.org/0000-0001-6505-8308

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Fumarate hydratase (FH)-deficient renal cell carcinoma (RCC) can exhibit striking histologic and immunophenotypic heterogeneity. A 36-year-old woman with uterine leiomyomas presented with a 5.1-cm left renal sinus mass and retroperitoneal adenopathy. Biopsy showed juxtaposed lower-grade oncocytic (PAX8 strong, GATA3 weak) and higher-grade pleomorphic (PAX8 negative, GATA3 and CK7 strong) components. DNA sequencing revealed germline pathogenic

Indexed as

case reportfumarate hydratase-deficient renal cell carcinomahereditary leiomyomatosisimmunoradiotherapylineage infidelitytumor evolution

Identifiers

PMID42317258
PMCPMC13272986

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.