Evidence map›Paper›PMID 42317228›Full record

ArticleMacromolecules2025

Enhanced Diffusion and Retention of Proteoglycan Replacements in Cartilage through Thermoresponsive Polyelectrolytes.

Shalini Sundar, Vidhika S Damani, Allison Koopman, Ai Nin Yang, Qurat-Ul-Ain Bhatti, Zoe A Fields, Weiran Xie, Jenna L Averill, Emily Yao, Sri Vishnuvardhan Reddy Akepati and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Macromolecules, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Dose-Dependent, Biomechanical Recovery of Permeability Ex Vivo in GAG-Depleted Cartilage With a Synthetic Polyelectrolyte, Polystyrene Sulfonate.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Shalini SundarDepartment of Biomedical Engineering, University of Delaware, Newark, DE, 19716, USA.
Vidhika S DamaniDepartment of Materials Science and Engineering, University of Delaware, Newark, DE, 19716, USA.
Allison KoopmanDepartment of Materials Science and Engineering, University of Delaware, Newark, DE, 19716, USA.
Ai Nin YangDepartment of Chemistry and Biochemistry, University of Delaware, Newark, DE, 19716, USA.
Qurat-Ul-Ain BhattiDepartment of Materials Science and Engineering, University of Delaware, Newark, DE, 19716, USA.
Zoe A FieldsDepartment of Biomedical Engineering, University of Delaware, Newark, DE, 19716, USA.
Weiran XieDepartment of Materials Science and Engineering, University of Delaware, Newark, DE, 19716, USA.
Jenna L AverillDepartment of Biomedical Engineering, University of Delaware, Newark, DE, 19716, USA.
Emily YaoDepartment of Chemical and Biomolecular Engineering, University of Delaware, Newark, DE, 19716, USA.
Sri Vishnuvardhan Reddy AkepatiData Science Program, University of Delaware, Newark, Delaware 19716, USA.
Arthi JayaramanDepartment of Materials Science and Engineering, University of Delaware, Newark, DE, 19716, USA.
Darrin J PochanDepartment of Materials Science and Engineering, University of Delaware, Newark, DE, 19716, USA.
Justin ParrenoDepartment of Biomedical Engineering, University of Delaware, Newark, DE, 19716, USA.
Laure V KayserDepartment of Materials Science and Engineering, University of Delaware, Newark, DE, 19716, USA.
Charles B DhongDepartment of Biomedical Engineering, University of Delaware, Newark, DE, 19716, USA.

Funding

X-ray Scattering Technology CoreP30GM133893 · NIGMS · BROOKHAVEN SCIENCE ASSOC-BROOKHAVEN LAB · PI Vivian Stojanoff · 2019 to 2026
$38.6M
Understanding synovial macrophage inflamm-aging within osteoarthritisP20GM139760 · NIGMS · UNIVERSITY OF DELAWARE · PI DAWN M ELLIOTT · 2021 to 2026
$19.1M
NIGMS NIH HHS P20 GM139760NIGMS NIH HHS P30 GM133893
6 · The paper itself

Abstract

During osteoarthritis (OA), negatively-charged proteoglycans are digested and lost from cartilage, which impairs tissue osmotic behavior and mechanical integrity, leading to further tissue degeneration. Existing strategies for introducing supplemental, soluble polyelectrolytes face barriers in compound performance in solid tissue: achieving sufficient tissue penetration by diffusion without losing the therapeutic in a short time by the same diffusive process. Here, we investigated thermo-responsive block copolymers, poly(styrene sulfonate)-

Indexed as

cartilagemultiphase diffusionosteoarthritispolyelectrolyte transportproteoglycan replacementthermal self-assembly

Identifiers

PMID42317228
PMCPMC13274708

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.