Evidence map›Paper›PMID 42317208›Full record

ArticleBone reports2026

The dinitrothiophenol SN-2 reduces osteoclastogenesis and estrogen deficiency-induced bone loss by inhibiting TRAF6 auto-ubiquitination.

Jian Lu, Huang Suo Wang, Jun Wang, Tao Fan, Jianbin Hu, Baotong Xun, Xiaodong Jia, Haoyu Feng, Haishan Guan, Yongwen Qiao and 1 more

Abstract read
In one paragraph

Article in Bone reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Jian LuDepartment of Neurosurgery, Inner Mongolia AeroSpace Hospital, China.
Huang Suo WangDepartment of Neurosurgery, the General Hospital of TISCO, Taiyuan, China.
Jun WangDepartment of Orthopedics, the General Hospital of TISCO, Taiyuan, China.
Tao FanDepartment of Orthopedics, the General Hospital of TISCO, Taiyuan, China.
Jianbin HuDepartment of Orthopedics, the General Hospital of TISCO, Taiyuan, China.
Baotong XunDepartment of Orthopedics, the General Hospital of TISCO, Taiyuan, China.
Xiaodong JiaDepartment of Orthopedics, the General Hospital of TISCO, Taiyuan, China.
Haoyu FengDepartment of Orthopedics, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Taiyuan, China.
Haishan GuanDepartment of Orthopedics, the Second Affiliated Clinical Medical College of Shanxi Medical University, Taiyuan, China.
Yongwen QiaoDepartment of Orthopedics, the General Hospital of TISCO, Taiyuan, China.
Feng GaoDepartment of Orthopedics, the General Hospital of TISCO, Taiyuan, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Post-menopausal osteoporosis is characterized by overactive bone resorption in response to estrogen withdrawal. As Receptor Activator of NF-κB ligand (RANKL)-induced auto-ubiquitination of TNF receptor-associated factor 6 (TRAF6) on its K124 residue promotes osteoclastogenesis, inhibiting TRAF6

Indexed as

Bone resorptionOsteoclastOsteoporosisRANKLTRAF6

Identifiers

PMID42317208
PMCPMC13273726

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.