Evidence map›Paper›PMID 42317112›Full record

ArticlePsychological medicine2026

DTI-ALPS and subcortical structural-functional coupling mediate the impact of sleep quality on working memory in insomnia disorder.

Zhangwei Lv, Haobo Zhang, Yinian Yang, Yuxian Wei, Xu Lei

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In one paragraph

Article in Psychological medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Zhangwei LvSleep and NeuroImaging Center, Faculty of Psychology, Southwest University, Chongqing, China.ORCID 0009-0006-4446-0617
Haobo ZhangSleep and NeuroImaging Center, Faculty of Psychology, Southwest University, Chongqing, China.
Yinian YangSleep and NeuroImaging Center, Faculty of Psychology, Southwest University, Chongqing, China.
Yuxian WeiSleep and NeuroImaging Center, Faculty of Psychology, Southwest University, Chongqing, China.
Xu LeiSleep and NeuroImaging Center, Faculty of Psychology, Southwest University, Chongqing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundWorking memory (WM) deficits are frequently observed in patients with insomnia disorder (ID), but their neural basis is unclear. Glymphatic dysfunction and disrupted structural-functional coupling have been implicated, yet they have rarely been examined together, particularly in clinical populations.

methodsWe conducted a multimodal MRI study in 391 ID patients. Glymphatic function was estimated using the diffusion tensor image analysis along the perivascular space (DTI-ALPS). The SFC was derived by correlating structural connectivity and functional connectivity. WM was measured by the longest span on the digit span backward task. Partial correlations and mediation analyses were performed to examine associations among sleep quality (Pittsburgh Sleep Quality Index, PSQI), DTI-ALPS, SFC, and WM performance.

resultsDTI-ALPS was negatively correlated with PSQI (

conclusionsThis study provides novel evidence that impaired glymphatic clearance and reduced Sub-SFC form key neural pathways linking poor sleep quality to working-memory deficits in ID, and that DTI-ALPS and Sub-SFC may serve as useful biomarkers of cognitive vulnerability.

Indexed as

Glymphatic SystemMemory, Short-TermSleep Initiation and Maintenance DisordersSleep QualityAdultDiffusion Tensor ImagingFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedDTI-ALPSglymphatic functioninsomnia disorderstructural-functional couplingsubcortical networkworking memory

Identifiers

PMID42317112
PMCPMC13280695

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.