Evidence map›Paper›PMID 42317078›Full record

ArticleChemical biology & drug design2026

Design, Synthesis of Novel Quinazolinone Derivatives and Evaluation of EGFR Kinase Inhibition Activity via In Vitro and In Silico Studies.

Aybüke Züleyha Kaya, Asaf Evrim Evren, Gülşen Akalın-Çiftçi, Leyla Yurttaş

Abstract read
In one paragraph

Article in Chemical biology & drug design, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Aybüke Züleyha KayaFaculty of Pharmacy, Department of Pharmaceutical Chemistry, Anadolu University, Eskisehir, Turkey.ORCID https://orcid.org/0009-0002-1614-2380
Asaf Evrim EvrenFaculty of Pharmacy, Department of Pharmaceutical Chemistry, Anadolu University, Eskisehir, Turkey.ORCID https://orcid.org/0000-0002-8651-826X
Gülşen Akalın-ÇiftçiFaculty of Pharmacy, Department of Biochemistry, Anadolu University, Eskisehir, Turkey.ORCID https://orcid.org/0000-0001-9535-2508
Leyla YurttaşFaculty of Pharmacy, Department of Pharmaceutical Chemistry, Anadolu University, Eskisehir, Turkey.ORCID https://orcid.org/0000-0002-0957-6044

Funding

Anadolu Üniversitesi TYL-2025-2850
6 · The paper itself

Abstract

Cancer is one of the most seen diseases worldwide. Due to the serious side effects of anticancer drugs and toxic effects on healthy cells, investigations for novel anticancer agents with low side effects have become one of the most important research areas of our age. With this objective, 17 new compounds were designed and successfully synthesized based on the quinazolinone, which is commonly found in the structures of FDA-approved EGFR inhibitors, and their structures were elucidated by IR, HRMS,

Indexed as

Antineoplastic AgentsDrug DesignProtein Kinase InhibitorsQuinazolinonesA549 CellsApoptosisCaspase 3Cell Line, TumorErbB ReceptorsGefitinibHumansMCF-7 CellsMolecular Docking SimulationStructure-Activity RelationshipAntineoplastic AgentsCaspase 3EGFR protein, humanErbB ReceptorsGefitinibProtein Kinase InhibitorsQuinazolinonesanticancerapoptosis inductioncaspase‐3 enzyme inhibitionEGFR inhibitionmolecular dynamics simulationsquinazolinone

Identifiers

PMID42317078
PMCPMC13280546

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.