Grisotti versus Wise-Pattern Oncoplastic Reconstruction in Central Breast Cancer: A Randomized Controlled Study.

Objective: Central breast tumors requiring excision of the nipple-areola complex present a reconstructive challenge in breast-conserving surgery. Volume-displacement oncoplastic techniques, including the Grisotti flap and reduction-based Wise-pattern reconstruction, allow breast preservation while maintaining oncological safety. This study compares the short-term oncological and aesthetic outcomes of these two techniques. Materials and Methods: A randomized controlled trial was conducted, enrolling 40 patients with centrally located breast cancer who underwent breast-conserving surgery between March 2023 and November 2024. Patients were randomized to reconstruction using either the Grisotti technique ( Results: Mean tumor size was 3.2±1.5 cm in the Grisotti group and 2.6±0.8 cm in the Wise-pattern group ( Conclusion: Both the Grisotti and Wise-pattern techniques demonstrated comparable short-term oncological safety and satisfactory aesthetic outcomes in breast-conserving surgery for central breast tumors. Differences in patient and surgeon satisfaction did not reach statistical significance. The Grisotti technique is most suitable for patients with small-to-moderate breast volumes and mild-to-moderate ptosis, while the Wise-pattern technique offers advantages in macromastia, significant ptosis, or when contralateral symmetrisation is planned. These findings support individualized technique selection based on breast volume and anatomical considerations, while highlighting the need for larger studies with longer follow-up to assess long-term oncological and aesthetic outcomes, and prospective use of validated aesthetic outcome instruments.