Evidence map›Paper›PMID 42316964›Full record

ReviewMolecular plant pathology2026

ESCRT: A Cellular Nexus of Plant Immunity and Pathogen Counter-Strategies.

Willam Kyle Sexton, Shunyuan Xiao

Abstract readReview
In one paragraph

Review in Molecular plant pathology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Willam Kyle SextonInstitute for Bioscience and Biotechnology Research, University of Maryland College Park, Rockville, Maryland, USA.
Shunyuan XiaoInstitute for Bioscience and Biotechnology Research, University of Maryland College Park, Rockville, Maryland, USA.

Funding

National Science Foundation IOS-2224203
6 · The paper itself

Abstract

The endosomal sorting complex required for transport (ESCRT) machinery consists of multiprotein complexes conserved across all eukaryotic lineages that function in several fundamental cellular processes. Among these are sorting endocytosed membrane proteins, multivesicular body (MVB) biogenesis, and autophagy. Despite the fact that these processes are also critical for plant immune responses, relatively little work has been done studying ESCRT in the context of plant immunity. Several studies indicate that ESCRT influences PAMP-triggered immunity (PTI) and effector-triggered immunity (ETI) by controlling the endosomal sorting of membrane-localized or associated immune signalling components, thereby affecting their localization and stability. Very few studies have examined ESCRT's role in MVB biogenesis during pathogen infection, but because ESCRT drives the formation of MVBs, it is likely involved in all the defence responses MVBs contribute to, such as extracellular vesicle (EV) release and cell wall reinforcement. Similarly, ESCRT's involvement in autophagy during pathogen infection is understudied, but because ESCRT is responsible for phagophore sealing, it is probably required for autophagy's roles in plant immunity, which include its complicated relationship with programmed cell death. ESCRT's relevance to plant immunity is also supported by instances of pathogen effectors targeting ESCRT complexes and evidence suggesting certain ESCRT subunits are monitored by the plant immune system. In this review, we highlight evidence supporting ESCRT's importance in plant immunity, discuss the mechanisms by which ESCRT contributes to immune responses, and identify the major knowledge gaps in this area.

Indexed as

Endosomal Sorting Complexes Required for TransportPlant ImmunityPlantsAutophagyMultivesicular BodiesEndosomal Sorting Complexes Required for Transport

Identifiers

PMID42316964
PMCPMC13280217

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.